甲型肝炎严重程度和过敏易感性的遗传控制。
Genetic control of hepatitis A severity and susceptibility to allergy.
机构信息
Université Paris Descartes, INSERM, Paris, France.
出版信息
J Clin Invest. 2011 Mar;121(3):848-50. doi: 10.1172/JCI46418. Epub 2011 Feb 21.
Abstract
Hepatitis A virus (HAV) usually results in asymptomatic infection or mild disease, but in a small subset of patients it can lead to severe disease and even liver failure. In this issue of the JCI, Kim et al. identify a polymorphism associated with this increased disease risk in the gene that encodes the HAV receptor--TIM1. Importantly, this TIM1 gene polymorphism protects from the development of atopic diseases in HAV-seropositive individuals.
摘要
甲型肝炎病毒（HAV）通常导致无症状感染或轻度疾病，但在一小部分患者中，它可导致严重疾病甚至肝衰竭。在本期 JCI 中，Kim 等人鉴定出编码 HAV 受体--TIM1 的基因中与这种疾病风险增加相关的一种多态性。重要的是，这种 TIM1 基因多态性可预防 HAV 血清阳性个体发生特应性疾病。
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