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Should anti-TNF-α drug levels and/or anti-drug antibodies be assayed in patients treated for rheumatoid arthritis?

作者信息

Mulleman Denis, Ducourau Emilie, Paintaud Gilles, Ternant David, Watier Hervé, Goupille Philippe

出版信息

Joint Bone Spine. 2012 Mar;79(2):109-12. doi: 10.1016/j.jbspin.2011.11.004. Epub 2012 Feb 20.

DOI:10.1016/j.jbspin.2011.11.004
PMID:22356754
Abstract
摘要

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Should anti-TNF-α drug levels and/or anti-drug antibodies be assayed in patients treated for rheumatoid arthritis?类风湿关节炎患者接受治疗时，是否应检测抗TNF-α药物水平和/或抗药物抗体？
Joint Bone Spine. 2012 Mar;79(2):109-12. doi: 10.1016/j.jbspin.2011.11.004. Epub 2012 Feb 20.
2
Effect of serum anti-tumour necrosis factor (TNF) drug trough concentrations and antidrug antibodies (ADAb) to further anti-TNF short-term effectiveness after switching in rheumatoid arthritis and axial spondyloarthritis.血清抗肿瘤坏死因子（TNF）药物谷浓度及抗药物抗体（ADAb）对类风湿关节炎和轴向脊柱关节炎换药后抗TNF短期疗效的影响。
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Is there a need for immunopharmacologic guidance of anti-tumor necrosis factor therapies?抗肿瘤坏死因子疗法是否需要免疫药理学指导？
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The frequency of anti-infliximab antibodies in patients with rheumatoid arthritis treated in routine care and the associations with adverse drug reactions and treatment failure.类风湿关节炎患者在常规治疗中抗英夫利昔单抗抗体的频率及其与药物不良反应和治疗失败的关系。
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TNF inhibitors: a new age in rheumatoid arthritis treatment.肿瘤坏死因子抑制剂：类风湿关节炎治疗的新时代。
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Clin Transl Sci. 2020 Jul;13(4):743-751. doi: 10.1111/cts.12760. Epub 2020 Apr 1.
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Model-Based Therapeutic Drug Monitoring of Infliximab Using a Single Serum Trough Concentration.基于模型的英夫利昔单抗单份血清谷浓度治疗药物监测。
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Practical recommendations for the use of therapeutic drug monitoring of biopharmaceuticals in inflammatory diseases.
炎症性疾病中生物制药治疗药物监测应用的实用建议。
Clin Pharmacol. 2017 Oct 3;9:101-111. doi: 10.2147/CPAA.S138414. eCollection 2017.
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Effect of Infliximab Dose Increase in Rheumatoid Arthritis at Different Trough Concentrations: A Cohort Study in Clinical Practice Conditions.不同谷浓度下英夫利昔单抗剂量增加对类风湿关节炎的影响：临床实践条件下的队列研究
Front Med (Lausanne). 2015 Oct 8;2:71. doi: 10.3389/fmed.2015.00071. eCollection 2015.
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Therapeutic vaccination with TNF-Kinoid in TNF antagonist-resistant rheumatoid arthritis: a phase II randomized, controlled clinical trial.使用肿瘤坏死因子类似物（TNF-Kinoid）对肿瘤坏死因子拮抗剂耐药的类风湿性关节炎进行治疗性疫苗接种：一项II期随机对照临床试验。
PLoS One. 2014 Dec 17;9(12):e113465. doi: 10.1371/journal.pone.0113465. eCollection 2014.
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Relationship between inflammation and infliximab pharmacokinetics in rheumatoid arthritis.类风湿关节炎中炎症与英夫利昔单抗药代动力学的关系。
Br J Clin Pharmacol. 2014 Jul;78(1):118-28. doi: 10.1111/bcp.12313.