Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Int J Gynaecol Obstet. 2012 May;117(2):178-81. doi: 10.1016/j.ijgo.2011.11.023. Epub 2012 Feb 20.
To investigate whether fallopian tube sperm perfusion (FSP) would improve pregnancy rates compared with standard intrauterine insemination (IUI) in cases of male factor infertility.
In a randomized controlled trial at a university teaching hospital in Egypt, 120 couples with mild or moderate male factor infertility underwent a mild controlled ovarian stimulation protocol (clomiphene citrate plus human menopausal gonadotropin). Women were randomly allocated to group 1 (FSP via Foley catheter with 4 mL of inseminate) or group 2 (standard IUI with 0.5 mL of inseminate) (n=60 for both). The main outcome measure was clinical pregnancy rate.
There were no significant differences between the groups in terms of baseline clinical characteristics, semen parameters, or characteristics of stimulation cycles. The pregnancy rate was significantly higher in group 1 than in group 2 (16 [26.7%] vs 7 [11.7%]; P<0.04). There was no significant difference in the incidence of multiple pregnancy, abortion, or ectopic pregnancy between the groups.
Fallopian tube sperm perfusion is an effective technique in the management of mild-moderate male factor infertility and should, therefore, be considered before resorting to more sophisticated techniques of assisted reproduction.
研究在男性因素不孕的情况下，与标准宫腔内人工授精（IUI）相比，输卵管内精子灌注（FSP）是否会提高妊娠率。
在埃及一所大学教学医院进行的一项随机对照试验中，120 对患有轻度或中度男性因素不孕的夫妇接受了轻度控制性卵巢刺激方案（克罗米芬枸橼酸加人绝经期促性腺激素）。女性被随机分配到第 1 组（通过 Foley 导管用 4 毫升授精液进行 FSP）或第 2 组（用 0.5 毫升授精液进行标准 IUI）（每组 60 例）。主要结局测量指标为临床妊娠率。
两组在基线临床特征、精液参数或刺激周期特征方面无显著差异。第 1 组的妊娠率明显高于第 2 组（16 [26.7%] 对 7 [11.7%]；P<0.04）。两组间多胎妊娠、流产或异位妊娠的发生率无显著差异。
输卵管内精子灌注是治疗轻度至中度男性因素不孕的有效技术，因此，在求助于更复杂的辅助生殖技术之前，应考虑该技术。
