Coard K, Escoffery C, Codrington G, Keeling J W, Ashley D
Department of Pathology, University of the West Indies, Kingston, Jamaica.
Pediatr Pathol. 1990;10(5):729-42. doi: 10.3109/15513819009064708.
Babies with major malformations were identified during the Jamaica Perinatal Morbidity and Mortality Survey. They were found in 96 (8.6%) of 1112 perinatal and neonatal deaths coming to necropsy and in 28 (2.6%) of 1085 no so examined. The central nervous system was most commonly affected, followed by the renal, gastrointestinal, and cardiovascular systems in decreasing order of frequency. Many infants had abnormalities in more than one system and 10 malformation syndromes/sequences were identified. Although at the present time, major malformations make only a small contribution to perinatal and neonatal mortality in Jamaica, their importance will increase when deaths from other causes, such as birth asphyxia, decline. The type of malformation currently fatal in a particular population is relevant when planning diagnostic and surgical services for neonates and infants. It is also important to any discussions about provision of prenatal diagnostic services.
在牙买加围产期发病率和死亡率调查中识别出患有严重畸形的婴儿。在1112例进行尸检的围产期和新生儿死亡病例中，有96例（8.6%）发现有严重畸形；在1085例未进行尸检的病例中，有28例（2.6%）发现有严重畸形。中枢神经系统受影响最为常见，其次是肾脏、胃肠道和心血管系统，按频率递减排序。许多婴儿存在不止一个系统的异常，并且识别出了10种畸形综合征/序列。虽然目前在牙买加，严重畸形对围产期和新生儿死亡率的影响较小，但当其他原因（如出生窒息）导致的死亡人数下降时，其重要性将会增加。在规划针对新生儿和婴儿的诊断及手术服务时，特定人群中目前致命的畸形类型具有相关性。这对于任何有关提供产前诊断服务的讨论也很重要。
