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出生时的先天性畸形。

Congenital malformations at birth.

作者信息

Swain S, Agrawal A, Bhatia B D

机构信息

Department of Obstetrics and Gynecology, Banaras Hindu University, Varanasi.

出版信息

Indian Pediatr. 1994 Oct;31(10):1187-91.

PMID:7875778
Abstract

Three thousand nine hundred and thirty-two consecutive newborns were examined at birth for the presence of congenital malformations. The overall incidence of malformations was 1.2%. Congenital malformations accounted for 9.2% of perinatal and 12.8% of neonatal deaths. The central nervous system (39.5%) was most commonly involved followed by musculoskeletal system (14.5%). Involvement of more than one system was observed in 18.8% cases. Though there was higher incidence of malformations in babies born to mothers of more than 35 years the difference was not statistically significant. However, the babies born to mothers of gravidity 4 or more had significantly higher incidence of malformation when compared to mothers of lower gravidity (chi1(2) = 4.67, p < 0.05). The incidence of congenital malformations at birth was higher in stillborn and low birthweight babies.

摘要

对3932例连续出生的新生儿进行了先天性畸形检查。畸形的总体发生率为1.2%。先天性畸形占围产期死亡的9.2%,新生儿死亡的12.8%。中枢神经系统(39.5%)受累最为常见,其次是肌肉骨骼系统(14.5%)。18.8%的病例观察到多个系统受累。虽然35岁以上母亲所生婴儿的畸形发生率较高,但差异无统计学意义。然而,与低孕次母亲相比,孕次为4次或以上母亲所生婴儿的畸形发生率显著更高(χ²(2)=4.67,p<0.05)。死产儿和低体重儿出生时先天性畸形的发生率较高。

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