Department of Clinical Biochemistry, Centre of Haemophilia and Thrombosis, Aarhus University Hospital, Brendstrupgaardsvej 100, Aarhus N 8200, Denmark.
Hum Reprod. 2012 May;27(5):1499-503. doi: 10.1093/humrep/des041. Epub 2012 Feb 21.
Case reports have reported venous and arterial thromboses in women undergoing assisted reproduction. No large systematic studies on the risk of thrombosis have been published. The objective of our study was to investigate whether the risk of thrombosis is increased in women undergoing assisted reproduction.
A national register-based cohort study was conducted on all women undergoing IVF or ICSI treatment in Denmark from 1994 to 2005. Data were obtained from the National Patient Registry and the IVF Registry. Women with prior malignant or cardiovascular disease were excluded. Thrombosis occurring within the first 6 and 12 months after assisted reproduction was considered potentially related to the treatment. Thromboses during pregnancy as well as the pregnancy-related diagnoses were excluded from the statistical analysis. The incidence rates of venous and arterial thromboses were compared with previously published estimates of the risk of thrombosis among young Danish women.
We analyzed 30 884 Danish women undergoing 75 141 treatments from 1994 to 2005. The mean age of the women at first treatment was 32.3 years. The delivery rate per cycle was 22%. The incidence rate ratio, with 95% confidence interval (CI), of venous thrombosis within 6 months was 0.95 (CI: 0.38-1.95). The incidence rate ratio of arterial thrombosis within 6 months was 0.36 (CI: 0.04-1.30).
Our study showed no evidence that assisted reproduction increases the risk of thrombosis.
已有病例报告称，接受辅助生殖的女性会发生静脉和动脉血栓形成。目前尚未发表关于血栓形成风险的大型系统性研究。我们的研究目的是调查接受辅助生殖的女性血栓形成的风险是否增加。
我们对 1994 年至 2005 年期间在丹麦接受体外受精或卵胞浆内单精子注射治疗的所有女性进行了一项全国基于登记的队列研究。数据来自国家患者登记处和体外受精登记处。排除了既往有恶性或心血管疾病的女性。将辅助生殖后 6 个月和 12 个月内发生的血栓形成视为可能与治疗相关。将妊娠期间以及与妊娠相关的诊断从统计分析中排除。比较了静脉和动脉血栓形成的发生率与先前发表的丹麦年轻女性血栓形成风险的估计值。
我们分析了 1994 年至 2005 年期间 30884 名接受 75141 次治疗的丹麦女性。首次治疗时女性的平均年龄为 32.3 岁。每个周期的分娩率为 22%。6 个月内静脉血栓形成的发病率比，95%置信区间（CI）为 0.95（CI：0.38-1.95）。6 个月内动脉血栓形成的发病率比为 0.36（CI：0.04-1.30）。
我们的研究没有证据表明辅助生殖会增加血栓形成的风险。
