Mahajan Nalini, Naidu Padmaja, Gupta Shalu, Rani Kumkum
Nova IVI Fertility, New Delhi, India.
J Hum Reprod Sci. 2015 Jul-Sep;8(3):182-5. doi: 10.4103/0974-1208.165150.
Deep venous thrombosis (DVT) has been reported extensively following ovarian hyperstimulation syndrome during in-vitro fertilization (IVF). Pregnancy per se increases the risk of DVT due to a hypercoagulable state. The long-term use of hormone replacement therapy (HRT) is another critical factor associated with DVT in women. However, an association between the short-term use of HRT in oocyte donation (OD) cycles and DVT has not yet been reported. We present a case of 43-year-old woman who developed DVT after IVF-OD. DVT was diagnosed at 7 weeks of pregnancy and was managed with low-molecular-weight heparin. We suggest that even a short-term use of HRT should be considered a risk factor for DVT especially in the presence of additional risk factors such as obesity. The patient had an uneventful recovery and delivered three healthy though preterm babies.
体外受精（IVF）期间，卵巢过度刺激综合征后广泛报道了深静脉血栓形成（DVT）。妊娠本身会因高凝状态而增加DVT的风险。长期使用激素替代疗法（HRT）是女性DVT的另一个关键相关因素。然而，尚未报道在卵母细胞捐赠（OD）周期中短期使用HRT与DVT之间的关联。我们报告一例43岁女性在IVF-OD后发生DVT的病例。DVT在妊娠7周时被诊断出来，并采用低分子量肝素进行治疗。我们建议，即使是短期使用HRT也应被视为DVT的一个危险因素，尤其是在存在肥胖等其他危险因素的情况下。该患者恢复顺利，产下了三个健康但早产的婴儿。
