Department of Radiology, University Medical Center Utrecht, HP E 01.132, PO Box 85500, 3508 GA Utrecht, the Netherlands.
Radiology. 2012 Mar;262(3):995-1001. doi: 10.1148/radiol.11110812.
To examine the multiple-layer appearance of the cerebral cortex with fluid-attenuated inversion recovery (FLAIR) magnetic resonance (MR) imaging at 7.0 T, whole-brain volumetric three-dimensional (3D) magnetization prepared FLAIR images were acquired in 12 volunteers (0.8 3 0.8 3 0.8-mm spatial resolution). Signal intensity profiles were evaluated for the anterior frontal (Brodmann area [BA] 10), posterior frontal (BA 6), parietal (BA 7), precentral (BA 4), postcentral (BA 3), occipital (BA 18), and calcarine (BA 17) regions. Variance of the normalized profile was used as the metric for the multiple-layer appearance. Wilcoxon signed-rank tests were performed to compare variances of the profiles between all areas. All cortical areas showed multiple-layered appearances, with a prominent hyperintense band at the external surface of the cortex, a hypointense band deeper in the cortex, and a hyperintense third band. The ranking from least- to most-pronounced layer appearance was as follows: postcentral (variance, 0.04), posterior frontal (variance, 0.05), calcarine (variance, 0.05), precentral (variance, 0.06), parietal (variance, 0.08), anterior frontal (variance, 0.10), and occipital (variance, 0.11). Each region was significantly different from at least one other region. In conclusion, a multiple-layer appearance of the cerebral cortex was found for all cortical regions with high-spatial-resolution 3D FLAIR MR imaging at 7.0 T.
为了在 7.0T 磁共振（MR）上用液体衰减反转恢复（FLAIR）技术检查大脑皮层的多层外观，对 12 名志愿者进行了全脑容积三维（3D）磁化准备 FLAIR 成像（空间分辨率为 0.8 3 0.8 3 0.8mm）。评估了前额（Brodmann 区[BA]10）、后额（BA6）、顶叶（BA7）、中央前回（BA4）、中央后回（BA3）、枕叶（BA18）和楔前回（BA17）区域的信号强度曲线。归一化曲线的方差被用作多层外观的指标。采用 Wilcoxon 符号秩检验比较所有区域之间的曲线方差。所有皮层区均表现出多层外观，在皮层外表面有一个明显的高信号带，皮层深部有一个低信号带，第三个带为高信号带。从最不明显到最明显的层外观的排名如下：中央后回（方差，0.04）、后额（方差，0.05）、楔前回（方差，0.05）、中央前回（方差，0.06）、顶叶（方差，0.08）、前额（方差，0.10）和枕叶（方差，0.11）。每个区域均与至少一个其他区域存在显著差异。总之，在 7.0T 高空间分辨率 3D FLAIR MR 成像上，所有皮层区均可见大脑皮层的多层外观。
