Department of Chemical Engineering, University of Sydney, 2006, NSW, Australia.
Cytotechnology. 1996 Jun;21(2):149-53. doi: 10.1007/BF02215664.
Recent advances in computer technology have promoted the design and use of detailed, computer-based models for biological systems. For many non-biological systems, the complexity of such simulations may be considered inappropriate and unwieldy, but in biological systems, and more specifically in animal cell culture, this level of complexity simply mimics what is only beginning to be understood about metabolic processs. With this in mind, we contend that complex, structured models are vital tools in the investigation of fundamental biological processes. An example of such a simulation, which describes the commercial production of therapeutic proteins by animal cell cultures, is considered.
计算机技术的最新进展促进了详细的、基于计算机的生物系统模型的设计和使用。对于许多非生物系统，这种模拟的复杂性可能被认为是不适当的和难以处理的，但在生物系统中，更具体地说，在动物细胞培养中，这种复杂程度只是模拟了对代谢过程的理解才刚刚开始。考虑到这一点，我们认为复杂的结构化模型是研究基本生物过程的重要工具。考虑了这样一个模拟的例子，该模拟描述了动物细胞培养物的商业生产治疗性蛋白质。
