结构生物学：毒蕈碱受体变得清晰明了。 - Suppr

Suppr

超能文献

Structural biology: Muscarinic receptors become crystal clear.

作者信息

Kow Rebecca L, Nathanson Neil M

出版信息

Nature. 2012 Feb 22;482(7386):480-1. doi: 10.1038/482480a.

DOI:10.1038/482480a

PMID:22358836

Abstract

摘要

相似文献

Structural biology: Muscarinic receptors become crystal clear.

Nature. 2012 Feb 22;482(7386):480-1. doi: 10.1038/482480a.

Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist.

Nature. 2012 Jan 25;482(7386):547-51. doi: 10.1038/nature10753.

A convenient synthesis of the muscarinic cholinergic antagonist (R)-[N-methyl- H]quinuclidinyl benzilate methiodide.

J Labelled Comp Radiopharm. 2019 Jul;62(9):604-607. doi: 10.1002/jlcr.3775.

Heterotropic cooperativity within and between protomers of an oligomeric M(2) muscarinic receptor.

Biochemistry. 2012 Jun 5;51(22):4518-40. doi: 10.1021/bi3000287. Epub 2012 May 24.

Muscarinic acetylcholine receptor X-ray structures: potential implications for drug development.

Curr Opin Pharmacol. 2014 Jun;16:24-30. doi: 10.1016/j.coph.2014.02.006. Epub 2014 Mar 21.

Distinct Agonist Regulation of Muscarinic Acetylcholine M2-M3 Heteromers and Their Corresponding Homomers.

J Biol Chem. 2015 Jun 5;290(23):14785-96. doi: 10.1074/jbc.M115.649079. Epub 2015 Apr 27.

Muscarinic receptor expression and receptor-mediated detrusor contraction: comparison of juvenile and adult porcine tissue.

Pflugers Arch. 2008 May;456(2):349-58. doi: 10.1007/s00424-007-0407-z. Epub 2007 Dec 21.

Alkyne-quinuclidine derivatives as potent and selective muscarinic antagonists for the treatment of COPD.

Bioorg Med Chem Lett. 2008 Apr 15;18(8):2675-8. doi: 10.1016/j.bmcl.2008.03.024. Epub 2008 Mar 18.

A mechanism for rapacuronium-induced bronchospasm: M2 muscarinic receptor antagonism.

Anesthesiology. 2003 Apr;98(4):906-11. doi: 10.1097/00000542-200304000-00017.

Muscarinic receptor subtype-specific effects on cigarette smoke-induced inflammation in mice.

Eur Respir J. 2013 Dec;42(6):1677-88. doi: 10.1183/09031936.00112412. Epub 2013 Feb 8.

引用本文的文献

Establishment of a CaCC-based Cell Model and Method for High-throughput Screening of M3 Receptor Drugs.

Cell Biochem Biophys. 2023 Mar;81(1):49-58. doi: 10.1007/s12013-022-01119-8. Epub 2022 Nov 29.

The deletion of M muscarinic receptors increases motor activity in females in the dark phase.

Brain Behav. 2018 Aug;8(8):e01057. doi: 10.1002/brb3.1057. Epub 2018 Jul 6.

Autoradiography of H-pirenzepine and H-AFDX-384 in Mouse Brain Regions: Possible Insights into M, M, and M Muscarinic Receptors Distribution.

Front Pharmacol. 2018 Feb 20;9:124. doi: 10.3389/fphar.2018.00124. eCollection 2018.

Accelerated molecular dynamics simulations of ligand binding to a muscarinic G-protein-coupled receptor.

Q Rev Biophys. 2015 Nov;48(4):479-87. doi: 10.1017/S0033583515000153.

Allosteric effects of sodium ion binding on activation of the m3 muscarinic g-protein-coupled receptor.

Biophys J. 2015 Apr 7;108(7):1796-1806. doi: 10.1016/j.bpj.2015.03.003.

Free energy landscape of G-protein coupled receptors, explored by accelerated molecular dynamics.

Phys Chem Chem Phys. 2014 Apr 14;16(14):6398-406. doi: 10.1039/c3cp53962h. Epub 2014 Jan 21.

Mapping of allosteric druggable sites in activation-associated conformers of the M2 muscarinic receptor.

Chem Biol Drug Des. 2014 Feb;83(2):237-46. doi: 10.1111/cbdd.12233. Epub 2013 Oct 30.

Activation and dynamic network of the M2 muscarinic receptor.

Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):10982-7. doi: 10.1073/pnas.1309755110. Epub 2013 Jun 18.

本文引用的文献

Structure and dynamics of the M3 muscarinic acetylcholine receptor.

Nature. 2012 Feb 22;482(7386):552-6. doi: 10.1038/nature10867.

Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist.

Nature. 2012 Jan 25;482(7386):547-51. doi: 10.1038/nature10753.

Molecular mechanism of β-arrestin-biased agonism at seven-transmembrane receptors.

Annu Rev Pharmacol Toxicol. 2012;52:179-97. doi: 10.1146/annurev.pharmtox.010909.105800. Epub 2011 Sep 19.

Crystal structure of the β2 adrenergic receptor-Gs protein complex.

Nature. 2011 Jul 19;477(7366):549-55. doi: 10.1038/nature10361.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验

Structural biology: Muscarinic receptors become crystal clear.

作者信息

Kow Rebecca L, Nathanson Neil M

出版信息

Nature. 2012 Feb 22;482(7386):480-1. doi: 10.1038/482480a.

DOI:10.1038/482480a

PMID:22358836

Abstract

摘要

相似文献

Structural biology: Muscarinic receptors become crystal clear.

Nature. 2012 Feb 22;482(7386):480-1. doi: 10.1038/482480a.

Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist.

Nature. 2012 Jan 25;482(7386):547-51. doi: 10.1038/nature10753.

A convenient synthesis of the muscarinic cholinergic antagonist (R)-[N-methyl- H]quinuclidinyl benzilate methiodide.

J Labelled Comp Radiopharm. 2019 Jul;62(9):604-607. doi: 10.1002/jlcr.3775.

Heterotropic cooperativity within and between protomers of an oligomeric M(2) muscarinic receptor.

Biochemistry. 2012 Jun 5;51(22):4518-40. doi: 10.1021/bi3000287. Epub 2012 May 24.

Muscarinic acetylcholine receptor X-ray structures: potential implications for drug development.

Curr Opin Pharmacol. 2014 Jun;16:24-30. doi: 10.1016/j.coph.2014.02.006. Epub 2014 Mar 21.

Distinct Agonist Regulation of Muscarinic Acetylcholine M2-M3 Heteromers and Their Corresponding Homomers.

J Biol Chem. 2015 Jun 5;290(23):14785-96. doi: 10.1074/jbc.M115.649079. Epub 2015 Apr 27.

Muscarinic receptor expression and receptor-mediated detrusor contraction: comparison of juvenile and adult porcine tissue.

Pflugers Arch. 2008 May;456(2):349-58. doi: 10.1007/s00424-007-0407-z. Epub 2007 Dec 21.

Alkyne-quinuclidine derivatives as potent and selective muscarinic antagonists for the treatment of COPD.

Bioorg Med Chem Lett. 2008 Apr 15;18(8):2675-8. doi: 10.1016/j.bmcl.2008.03.024. Epub 2008 Mar 18.

A mechanism for rapacuronium-induced bronchospasm: M2 muscarinic receptor antagonism.

Anesthesiology. 2003 Apr;98(4):906-11. doi: 10.1097/00000542-200304000-00017.

Muscarinic receptor subtype-specific effects on cigarette smoke-induced inflammation in mice.

Eur Respir J. 2013 Dec;42(6):1677-88. doi: 10.1183/09031936.00112412. Epub 2013 Feb 8.

引用本文的文献

Establishment of a CaCC-based Cell Model and Method for High-throughput Screening of M3 Receptor Drugs.

Cell Biochem Biophys. 2023 Mar;81(1):49-58. doi: 10.1007/s12013-022-01119-8. Epub 2022 Nov 29.

The deletion of M muscarinic receptors increases motor activity in females in the dark phase.

Brain Behav. 2018 Aug;8(8):e01057. doi: 10.1002/brb3.1057. Epub 2018 Jul 6.

Autoradiography of H-pirenzepine and H-AFDX-384 in Mouse Brain Regions: Possible Insights into M, M, and M Muscarinic Receptors Distribution.

Front Pharmacol. 2018 Feb 20;9:124. doi: 10.3389/fphar.2018.00124. eCollection 2018.

Accelerated molecular dynamics simulations of ligand binding to a muscarinic G-protein-coupled receptor.

Q Rev Biophys. 2015 Nov;48(4):479-87. doi: 10.1017/S0033583515000153.

Allosteric effects of sodium ion binding on activation of the m3 muscarinic g-protein-coupled receptor.

Biophys J. 2015 Apr 7;108(7):1796-1806. doi: 10.1016/j.bpj.2015.03.003.

Free energy landscape of G-protein coupled receptors, explored by accelerated molecular dynamics.

Phys Chem Chem Phys. 2014 Apr 14;16(14):6398-406. doi: 10.1039/c3cp53962h. Epub 2014 Jan 21.

Mapping of allosteric druggable sites in activation-associated conformers of the M2 muscarinic receptor.

Chem Biol Drug Des. 2014 Feb;83(2):237-46. doi: 10.1111/cbdd.12233. Epub 2013 Oct 30.

Activation and dynamic network of the M2 muscarinic receptor.

Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):10982-7. doi: 10.1073/pnas.1309755110. Epub 2013 Jun 18.

本文引用的文献

Structure and dynamics of the M3 muscarinic acetylcholine receptor.

Nature. 2012 Feb 22;482(7386):552-6. doi: 10.1038/nature10867.

Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist.

Nature. 2012 Jan 25;482(7386):547-51. doi: 10.1038/nature10753.

Molecular mechanism of β-arrestin-biased agonism at seven-transmembrane receptors.

Annu Rev Pharmacol Toxicol. 2012;52:179-97. doi: 10.1146/annurev.pharmtox.010909.105800. Epub 2011 Sep 19.

Crystal structure of the β2 adrenergic receptor-Gs protein complex.

Nature. 2011 Jul 19;477(7366):549-55. doi: 10.1038/nature10361.