Orlandi F, Damiani G, Jakil C, Lauricella S, Bertolino O, Maggio A
Servizio di Diagnosi Prenatale, Ospedale V. Cervello, Palermo, Italy.
Prenat Diagn. 1990 Jul;10(7):425-8. doi: 10.1002/pd.1970100703.
Five hundred cordocenteses were performed between 12 and 21 weeks. The indications were thalassaemia (386), rapid karyotyping (97), feto-maternal allo-immunization (10), rubella (6), and toxoplasmosis (1). One hundred and ten pregnancies underwent termination on the basis of the result, while 20 of the 370 pregnancies intended to continue were lost to follow-up. Amongst these were 16 fetal losses (4.3 per cent) and 22 premature deliveries (5.9 per cent); no other complications were reported. Four adverse prognostic factors were identified: (a) cord bleeding; (b) fetal bradycardia; (c) prolonged procedure time; and (d) anterior insertion of the placenta. There was no 'obvious' difference in fetal loss rate with advancing gestation until 19-21 weeks, when the risk of fetal loss decreased to 2.5 per cent.
在孕12至21周期间进行了500次脐带穿刺术。其适应证包括地中海贫血（386例）、快速核型分析（97例）、胎儿-母体血型不合（10例）、风疹（6例）和弓形虫病（1例）。110例妊娠根据检查结果终止妊娠，而计划继续妊娠的370例中有20例失访。其中有16例胎儿丢失（4.3%）和22例早产（5.9%）；未报告其他并发症。确定了四个不良预后因素：（a）脐带出血；（b）胎儿心动过缓；（c）操作时间延长；（d）胎盘前置。直到孕19至21周，随着孕周增加，胎儿丢失率无“明显”差异，此时胎儿丢失风险降至2.5%。
