Department of Psychiatry and Psychotherapy, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.
Neuropsychol Rev. 2012 Sep;22(3):298-309. doi: 10.1007/s11065-012-9193-2. Epub 2012 Feb 23.
Identifying risk factors for Alzheimer's disease, such as carrying the APOE-4 allele, and understanding their contributions to disease pathophysiology or clinical presentation is critical for establishing and improving diagnostic and therapeutic strategies. A first-degree family history of Alzheimer's disease represents a composite risk factor, which reflects the influence of known and unknown susceptibility genes and perhaps non-genetic risks. There is emerging evidence that investigating family history risk associated effects may contribute to advances in Alzheimer's disease research and ultimately clinical practice.
确定阿尔茨海默病的风险因素,如携带 APOE-4 等位基因,并了解它们对疾病病理生理学或临床表现的贡献,对于制定和改进诊断和治疗策略至关重要。阿尔茨海默病的一级家族史代表了一个综合风险因素,反映了已知和未知的易感基因以及可能的非遗传风险的影响。有新的证据表明,研究家族史风险相关效应可能有助于推进阿尔茨海默病的研究,并最终应用于临床实践。