Singh S M, Reber H A
Department of Surgery, UCLA School of Medicine.
Pancreas. 1990 Sep;5(5):568-73. doi: 10.1097/00006676-199009000-00012.
We created acute pancreatitis in cats by instilling ethanol (20 ml of a 40% solution) into the stomach and then perfusing activated pancreatic enzymes through the main pancreatic duct. Edematous pancreatitis developed within 24 h as the enzymes leaked out of the duct into the surrounding pancreatic parenchyma. We tested the effects of a number of agents on the amelioration of the severity of the pancreatic inflammation. Cimetidine (an H2 receptor blocker) and Benadryl (an H1 receptor blocker) given in combination decreased the incidence of pancreatic hemorrhage but not the overall degree of inflammation. Indomethacin (a cyclooxygenase inhibitor) had a similar effect. Terbutaline (a beta-agonist) given alone decreased the overall degree of inflammation, including the incidence of hemorrhage. All of the drugs given together were no more effective than terbutaline alone. The combination was effective even when given up to 12 h after the onset of pancreatitis.
我们通过向猫的胃内注入乙醇（20毫升40%的溶液），然后通过主胰管灌注活化的胰酶来制造急性胰腺炎。随着酶从导管漏出进入周围的胰腺实质，在24小时内出现了水肿性胰腺炎。我们测试了多种药物对减轻胰腺炎症严重程度的效果。联合使用西咪替丁（一种H2受体阻滞剂）和苯海拉明（一种H1受体阻滞剂）可降低胰腺出血的发生率，但不能减轻整体炎症程度。吲哚美辛（一种环氧化酶抑制剂）有类似效果。单独使用特布他林（一种β受体激动剂）可减轻整体炎症程度，包括出血的发生率。所有药物联合使用并不比特布他林单独使用更有效。即使在胰腺炎发作后12小时给药，这种联合用药仍有效。
