Koul Roshan, Al-Futaisi Amna, Chacko Alexander, Fazalullah Mohammed, Nabhani Susan Al, Al-Awaidy Salah, Al-Busaidy Suleiman, Al-Mahrooqi Salim
Oman Med J. 2008 Jul;23(3):158-61.
To find the incidence, clinical pattern and outcome of Guillain-Barre syndrome in the Sultanate of Oman in children less than 15 years of age.
All children under fifteen years with acute flaccid paralysis were admitted to identify the underlying cause. The diagnosis of Gullain Barre syndrome was made by clinical criteria, cerebrospinal fluid findings and nerve conduction studies. Intravenous immunoglobulins were given to all and two needed plasmapharesis.
Sixty-one children were diagnosed as Guillan-Barré syndrome and constituted 20% of cases of acute flaccid paralysis. Males 39 (63.9%) outnumbered females (36.1%).The annual incidence below 15 years was 0.45/100,000. Cranial nerves were involved in 31 (50.8%) children. Albumino-cytological dissociation in cerebrospinal fluid was seen in 42/45(93.3%) cases. Acute relapse was seen in six (9.8%) cases. Eleven children (18.3%) needed ventilation. Complete recovery was seen in 45 to 310 days (mean 69.1 days). Three children (4.9%) were left with minimal residual deficit. There was no mortality.
Guillain Barre syndrome is a serious disease, although recovery is the rule in children. The disease is associated with very low mortality and long term morbidity. Immunoglobulins have reduced the duration of hospital stay and the total time needed for recovery.
确定阿曼苏丹国15岁以下儿童吉兰-巴雷综合征的发病率、临床模式及预后情况。
所有15岁以下急性弛缓性麻痹患儿均入院以明确潜在病因。吉兰-巴雷综合征的诊断依据临床标准、脑脊液检查结果及神经传导研究做出。所有患儿均给予静脉注射免疫球蛋白，2例需要进行血浆置换。
61名儿童被诊断为吉兰-巴雷综合征，占急性弛缓性麻痹病例的20%。男性39例（63.9%）多于女性（36.1%）。15岁以下儿童的年发病率为0.45/10万。31例（50.8%）儿童累及颅神经。45例中有42例（93.3%）脑脊液出现蛋白-细胞分离现象。6例（9.8%）出现急性复发。11名儿童（18.3%）需要通气支持。45至310天（平均69.1天）实现完全恢复。3名儿童（4.9%）留有轻微残余功能障碍。无死亡病例。
吉兰-巴雷综合征是一种严重疾病，不过儿童通常能够康复。该疾病死亡率极低，长期发病率也较低。免疫球蛋白缩短了住院时间及恢复所需的总时长。
