Neuroscience Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Paramedic Faculty, Neuroscience Research Center, Guilan University of Medical Sciences, Rasht, Iran.
Neurol Sci. 2022 Mar;43(3):1929-1938. doi: 10.1007/s10072-021-05562-y. Epub 2021 Aug 17.
Guillain-Barré syndrome (GBS) is the main cause of acute and subacute flaccid paralysis in western nations since the eradication of poliomyelitis.
The aim of this study is to investigate epidemiology and mortality characteristics of GBS in the north of Iran.
In this study, the hospital information system (HIS) was used to access each patient's information. The final 174 cases were examined in terms of age, sex, place of residence, the year of referral, the month of referral, the season of referral, client city, accompanying background disease, and the type of GBS.
The mean incidence rate in Guilan province was about 0.69 in 100,000 persons, and the case fatality rate was 10.34%. The most reported type of GBS was AIDP (33.90%), and the most common symptom was upper and lower limbs paresis in 65 cases (37%). Respiratory distress (P = < 0.001), complications during hospitalization (P = 0.0001), and ICU requirement (P = 0.001) were significantly higher in dead patients.
In this study, the incidence of GBS was higher in men than women and the highest number of cases was in the age group of 60 to 75 years. The significant point was the high-case fatality rate in Guilan province compared to the previous studies. The complications during hospitalization such as respiratory distress, ICU requirement, and underlying disease had a significant relation with the fatality of GBS.
在小儿麻痹症根除后，吉兰-巴雷综合征（GBS）成为西方国家急性和亚急性弛缓性瘫痪的主要原因。
本研究旨在探讨伊朗北部 GBS 的流行病学和死亡率特征。
本研究利用医院信息系统（HIS）获取每位患者的信息。最终检查了 174 例患者的年龄、性别、居住地、就诊年份、就诊月份、就诊季节、就诊城市、伴随背景疾病和 GBS 类型。
吉兰省的平均发病率约为每 10 万人 0.69 例，病死率为 10.34%。报告最多的 GBS 类型是 AIDP（33.90%），最常见的症状是 65 例（37%）上下肢无力。呼吸窘迫（P < 0.001）、住院期间并发症（P = 0.0001）和需要 ICU 治疗（P = 0.001）在死亡患者中显著更高。
在这项研究中，GBS 的发病率男性高于女性，60 至 75 岁年龄组的病例最多。重要的是，与之前的研究相比，吉兰省的病死率较高。住院期间的并发症，如呼吸窘迫、需要 ICU 治疗和基础疾病，与 GBS 的病死率有显著关系。
