Chandrasekhar M R, Krishna B V S, Patil Asha B
Department of Microbiology, Raichur Institute of Medical Sciences, Raichur, India.
Southeast Asian J Trop Med Public Health. 2008 Nov;39(6):1092-7.
The serogroups and antimicrobial susceptibility patterns of V. cholerae isolated in Hubli, India during the years 2000 to 2004 were monitored. A total of 256 V. cholerae isolates were obtained during the study period, of which 129 (50.4%) belonged to serogroup O1 while the O139 and non-O1, non-O139 serogroups constituted 61 (23.8%) and 66 (25.8%) isolates, respectively. V. cholerae O1 Ogawa was the predominant isolate during the first 2 years of the study. However, this was replaced by V. cholerae non-O1, non-O139 serogroups in the following years. The V. cholerae, which was susceptible to most enteric antimicrobials in 2000, was found to be multidrug resistant in subsequent years, with the development of fluroquinolone resistance since 2002. Surveillance of the epidemiological and microbiological characteristics of V. cholerae provides useful information for managing cholera cases. The V. cholerae non-O1, non-O139 serogroups coupled with multiple antimicrobial resistance may form a group of emerging diarrheal pathogens in the tropics.
对2000年至2004年期间在印度胡布利分离出的霍乱弧菌血清群和抗菌药物敏感性模式进行了监测。在研究期间共获得256株霍乱弧菌分离株，其中129株（50.4%）属于O1血清群，而O139血清群以及非O1、非O139血清群分别占61株（23.8%）和66株（25.8%）。在研究的头两年，霍乱弧菌O1小川型是主要的分离株。然而，在随后几年中被非O1、非O139血清群的霍乱弧菌所取代。2000年对大多数肠道抗菌药物敏感的霍乱弧菌，在随后几年中被发现具有多重耐药性，自2002年以来出现了对氟喹诺酮的耐药性。对霍乱弧菌的流行病学和微生物学特征进行监测可为霍乱病例的管理提供有用信息。非O1、非O139血清群的霍乱弧菌加上多重抗菌药物耐药性可能在热带地区形成一组新出现的腹泻病原体。
