三并噻吩，一种来自蜣螂粪球内链霉菌属的含环丁烷的三环内酰胺。
Tripartilactam, a cyclobutane-bearing tricyclic lactam from a Streptomyces sp. in a dung beetle's brood ball.
机构信息
Natural Products Research Institute, College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea.
出版信息
Org Lett. 2012 Mar 2;14(5):1258-61. doi: 10.1021/ol300108z. Epub 2012 Feb 23.
Tripartilactam, a structurally unprecedented cyclobutane-bearing tricyclic lactam metabolite, was discovered from Streptomyces sp. isolated from a brood ball of the dung beetle, Copris tripartitus. The structure of this compound was elucidated by the combination of NMR, MS, UV, and IR spectroscopy and multistep chemical derivatization. Tripartilactam was evaluated as a Na(+)/K(+) ATPase inhibitor (IC(50) = 16.6 μg/mL).
三并噻唑烷酮，一种结构上从未有过的含环丁烷的三环内酰胺代谢产物，是从蜣螂Copris tripartitus 的粪球中分离出的链霉菌属菌株中发现的。通过 NMR、MS、UV 和 IR 光谱以及多步化学衍生化的组合，阐明了该化合物的结构。三并噻唑烷酮被评估为 Na(+)/K(+)ATP 酶抑制剂（IC(50)=16.6μg/mL）。
Zotero 插件