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银屑病和特应性皮炎患者血清 CRH 水平升高，皮肤 CRHR-1 基因表达降低。

Increased serum CRH levels with decreased skin CRHR-1 gene expression in psoriasis and atopic dermatitis.

出版信息

J Allergy Clin Immunol. 2012 May;129(5):1410-3. doi: 10.1016/j.jaci.2012.01.041. Epub 2012 Feb 22.

DOI:10.1016/j.jaci.2012.01.041
PMID:22360979
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3340539/
Abstract

There is increased serum CRH with decreased lesional skin CRHR-1 gene expression in psoriasis and atopic dermatitis, suggesting possible involvement in stress-induced worsening of symptoms.

摘要

银屑病和特应性皮炎患者血清 CRH 增加，皮损皮肤 CRHR-1 基因表达减少，提示其可能参与应激诱导的症状恶化。

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本文引用的文献

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Substance P (SP) induces expression of functional corticotropin-releasing hormone receptor-1 (CRHR-1) in human mast cells.P 物质（SP）诱导人肥大细胞表达功能性促肾上腺皮质激素释放激素受体-1（CRHR-1）。
J Invest Dermatol. 2012 Feb;132(2):324-9. doi: 10.1038/jid.2011.334. Epub 2011 Nov 17.
2
Contrasting pathogenesis of atopic dermatitis and psoriasis--part I: clinical and pathologic concepts.特应性皮炎和银屑病发病机制的对比——第 1 部分：临床和病理概念。
J Allergy Clin Immunol. 2011 May;127(5):1110-8. doi: 10.1016/j.jaci.2011.01.053. Epub 2011 Mar 8.
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On the role of the corticotropin-releasing hormone signalling system in the aetiology of inflammatory skin disorders.促肾上腺皮质激素释放激素信号系统在炎症性皮肤病病因学中的作用
Br J Dermatol. 2009 Feb;160(2):229-32. doi: 10.1111/j.1365-2133.2008.08958.x.
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Reliability and psychometric properties of the Greek translation of the State-Trait Anxiety Inventory form Y: preliminary data.状态-特质焦虑量表Y型希腊语翻译版的信度和心理测量学特性：初步数据
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J Neuroimmunol. 2004 Jan;146(1-2):1-12. doi: 10.1016/j.jneuroim.2003.10.041.
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Corticotropin-releasing hormone causes vasodilation in human skin via mast cell-dependent pathways.促肾上腺皮质激素释放激素通过肥大细胞依赖性途径引起人体皮肤血管舒张。
J Clin Endocrinol Metab. 2003 Nov;88(11):5427-32. doi: 10.1210/jc.2003-030377.
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Neuroendocrinology of the skin.皮肤的神经内分泌学
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Corticotropin-releasing hormone induces skin mast cell degranulation and increased vascular permeability, a possible explanation for its proinflammatory effects.促肾上腺皮质激素释放激素可诱导皮肤肥大细胞脱颗粒并增加血管通透性，这可能是其促炎作用的一种解释。
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