Chase Elizabeth P, Armstrong April W
Dermatology Clinical Research Unit, Department of Dermatology, University of California, Davis, Sacramento, CA 95816, USA.
Semin Cutan Med Surg. 2012 Mar;31(1):17-24. doi: 10.1016/j.sder.2011.11.005.
Atopic dermatitis (AD) is a chronic inflammatory skin condition marked by intensely pruritic, eczematous changes. First-line therapy includes topical corticosteroids during an exacerbation and long-term emollient use, followed by topical calcineurin inhibitors, phototherapy, and systemic therapy in more difficult cases. The need for more effective AD therapies with safer side effect profiles has pushed researchers to devise new therapies and to recycle traditional treatments for use in a novel manner. Innovative therapies include barrier therapy, novel antistaphylococcal treatments, new immunomodulatory agents, unconventional antipruritic agents, exclusionary diets, and probiotics. Advancements in these options have paved the way for a targeted approach to AD therapy. We will review the latest clinical research exploring these cutting-edge AD treatment modalities and discuss forward-thinking therapy strategies that use conventional AD medications in a novel manner.
特应性皮炎（AD）是一种慢性炎症性皮肤病，其特征为剧烈瘙痒和湿疹样改变。一线治疗包括在病情加重时使用外用糖皮质激素以及长期使用润肤剂，随后在病情更复杂的情况下使用外用钙调神经磷酸酶抑制剂、光疗和系统治疗。对具有更安全副作用的更有效AD治疗方法的需求促使研究人员设计新的治疗方法，并以新颖的方式重新利用传统治疗方法。创新疗法包括屏障疗法、新型抗葡萄球菌治疗、新的免疫调节剂、非常规止痒剂、排除饮食和益生菌。这些治疗选择的进展为AD治疗的靶向方法铺平了道路。我们将回顾探索这些前沿AD治疗方式的最新临床研究，并讨论以新颖方式使用传统AD药物的前瞻性治疗策略。
