[非甾体抗炎药。2-(4-联苯基)-3-羟基丙酸同系物的立体异构体。十二]
[Non-steroidal anti-inflammatory agents. Stereoisomers of homologues of 2-(4-biphenylyl)-3-hydroxypropionic acid. XII].
作者信息
Burnelli S, Guarnieri A, Varoli L, Cesaroni M R, Scapini G
出版信息
Farmaco Sci. 1983 May;38(5):340-51.
PMID:6862004
Abstract
The synthesis of some homologues of 2-(4-biphenylyl)-3-hydroxypropionic acid, the separation of related diastereoisomers, their attribution to erythro and threo series, and resolution of the optical antipodes are described. The antiinflammatory activity--initially tested by carrageenin assay--proves generally influenced by steric configuration and is interesting for the isohexanoic derivative.
摘要
描述了2-(4-联苯基)-3-羟基丙酸的一些同系物的合成、相关非对映异构体的分离、它们对赤藓糖型和苏阿糖型系列的归属以及旋光对映体的拆分。抗炎活性——最初通过角叉菜胶试验进行测试——总体上证明受空间构型的影响，并且异己酸衍生物的抗炎活性很有趣。
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