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[Non-steroidal anti-inflammatory agents. Stereoisomers of homologues of 2-(4-biphenylyl)-3-hydroxypropionic acid. XII].

作者信息

Burnelli S, Guarnieri A, Varoli L, Cesaroni M R, Scapini G

出版信息

Farmaco Sci. 1983 May;38(5):340-51.

PMID:6862004
Abstract

The synthesis of some homologues of 2-(4-biphenylyl)-3-hydroxypropionic acid, the separation of related diastereoisomers, their attribution to erythro and threo series, and resolution of the optical antipodes are described. The antiinflammatory activity--initially tested by carrageenin assay--proves generally influenced by steric configuration and is interesting for the isohexanoic derivative.

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