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[非甾体抗炎药。IV. 含吡咯基团的芳酰噻吩乙酸的合成及药理活性]

[Non-steroidal anti-inflammatory agents. IV. Synthesis and pharmacologic activity of aroylthiopheneacetic acids with a pyrrole group].

作者信息

Massa S, Stefancich G, Artico M, Corelli F, Pantaleoni G C, Palumbo G, Fanini D, Giorgi R

出版信息

Farmaco Sci. 1986 Apr;41(4):281-91.

PMID:3486782
Abstract

The synthesis of new antiinflammatory aroylthiopheneacetic acids bearing a pyrrole moiety is described. These compounds can be regarded as analogues of thiaprofen and related isosteres. The antiinflammatory activity of the new pyrryl derivatives has been evaluated in comparison with indomethacin, tolmetin and the unknown 5-(2-chlorobenzoyl)thiophene-2-acetic acid. Among tested derivatives the compounds containing the pyrrole ring were devoid of analgesic-antiinflammatory activities.

摘要

描述了带有吡咯部分的新型抗炎芳酰基噻吩乙酸的合成。这些化合物可被视为噻洛芬及相关电子等排体的类似物。已将新型吡咯衍生物的抗炎活性与吲哚美辛、托美丁和未知的5-(2-氯苯甲酰基)噻吩-2-乙酸进行了比较评估。在所测试的衍生物中，含有吡咯环的化合物没有镇痛抗炎活性。

相似文献

1
[Non-steroidal anti-inflammatory agents. IV. Synthesis and pharmacologic activity of aroylthiopheneacetic acids with a pyrrole group].[非甾体抗炎药。IV. 含吡咯基团的芳酰噻吩乙酸的合成及药理活性]
Farmaco Sci. 1986 Apr;41(4):281-91.
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Farmaco Sci. 1984 Sep;39(9):765-80.
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[Nonsteroidal anti-inflammatory agents. V. Synthesis of 1-aryl-5-(1-pyrryl)-pyrazolyl-4-acetic acids with potential anti-inflammatory action].[非甾体抗炎药。V. 具有潜在抗炎作用的1-芳基-5-(1-吡咯基)-吡唑基-4-乙酸的合成]
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Synthesis, neuropsychopharmacological effects and analgesic-antiinflammatory activities of pyrrole analogues of lefetamine.左非他明吡咯类似物的合成、神经精神药理学效应及镇痛抗炎活性
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Synthesis and pharmacological properties of benzothienothiadiazolopyrimidine derivatives. III.
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