通过串联钯催化的分子内氨羰化环合反应，实现了 3-取代-1(2H)-异喹啉酮的新方法。
A new access to 3-substituted-1(2H)-isoquinolone by tandem palladium-catalyzed intramolecular aminocarbonylation annulation.
机构信息
Institut Curie, Centre de Recherche, 26 rue d'Ulm, Paris 75248, France.
出版信息
Org Biomol Chem. 2012 Apr 7;10(13):2683-91. doi: 10.1039/c2ob06852d. Epub 2012 Feb 24.
PMID:22362022
Abstract
An original tribromide derivative based, palladium-catalyzed synthesis of 3-substituted-1(2H)-isoquinolone is described based on a regioselective Suzuki-Miyaura C-C coupling on o-halo-(2,2-dihalovinyl)-benzene followed by a palladium catalyzed amination-carbonylation-cyclization reaction. This sequence efficiently proceeds to build up isoquinolone in fair to good yields over a one-pot 3-bond synthesis reaction.
摘要
本文描述了一种基于三溴化物衍生物、钯催化的 3-取代-1(2H)-异喹啉酮的合成方法，该方法基于邻卤-(2,2-二卤乙烯基)苯的区域选择性铃木-宫浦 C-C 偶联反应，然后进行钯催化的氨基化-羰基化-环化反应。该序列通过一锅 3 键合成反应有效地进行，在较温和的条件下以中等到良好的收率构建异喹啉酮。
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