Peters V G, Wyman D R, Patterson M S, Frank G L
Hamilton Regional Cancer Centre, Ontario, Canada.
Phys Med Biol. 1990 Sep;35(9):1317-34. doi: 10.1088/0031-9155/35/9/010.
The optical absorption and scattering coefficients have been determined for specimens of normal and diseased human breast tissues over the range of wavelengths from 500 to 1100 nm. Total attenuation coefficients were measured for thin slices of tissue cut on a microtome. The diffuse reflectance and transmittance were measured for 1.0 mm thick samples of these tissues, using standard integrating sphere techniques. Monte Carlo simulations were performed to derive the scattering and absorption coefficients, as well as the mean cosine of the scattering angle. The results indicate that scatter exceeds absorption by at least two orders of magnitude. Absorption is most significant at wavelengths below 600 nm. The scattering coefficients lie in the range 30-90 mm-1 at 500 nm, and fall smoothly with increasing wavelength to between 10 and 50 mm-1 at 1100 nm. The scattering coefficient for adipose tissue differs, in that it is invariant with wavelength over this spectral range. For all tissues examined, the scattered light is highly forward peaked, with the mean cosine of the scattering angle in the range 0.945-0.985. Systematic differences between the optical properties of some tissue types are demonstrated.
已测定了正常和病变人类乳腺组织标本在500至1100纳米波长范围内的光吸收系数和散射系数。使用切片机切割的薄组织切片测量了总衰减系数。利用标准积分球技术测量了这些组织1.0毫米厚样本的漫反射率和透射率。进行了蒙特卡罗模拟以推导散射系数、吸收系数以及散射角的平均余弦值。结果表明，散射比吸收至少高两个数量级。在波长低于600纳米时吸收最为显著。在500纳米处，散射系数在30 - 90毫米⁻¹范围内，并且随着波长增加而平滑下降，在1100纳米处降至10至50毫米⁻¹之间。脂肪组织的散射系数有所不同，在该光谱范围内它不随波长变化。对于所有检查的组织，散射光高度向前集中，散射角的平均余弦值在0.945 - 0.985范围内。展示了一些组织类型光学特性之间的系统差异。
