Department of Normal, Pathological and Clinical Physiology, Third Faculty of Medicine, Charles University in Prague, Ke Karlovu 4, 120 00 Prague 2, Czech Republic.
Dev Psychobiol. 2013 Apr;55(3):232-42. doi: 10.1002/dev.21016. Epub 2012 Feb 23.
The aim of the present study was to compare the response to sub-chronic application of methamphetamine (MA) in adulthood in male and female rats prenatally exposed to the same drug. The spontaneous locomotor activity and exploratory behavior of adult male and female rats prenatally exposed to 5 mg/kg MA or saline (SAL) were tested in a Laboras apparatus (Metris B.V., Netherlands) for five consecutive days, 1 hr daily. MA 1 mg/kg or SAL were used as a challenge prior to testing. Our results showed that rats prenatally exposed to MA were more sensitive to sub-chronic administration of MA in adulthood than prenatally SAL-exposed rats. However, this sensitizing effect of prenatal MA exposure was manifested differently in males and females. In contrast, prenatal MA exposure decreased baseline locomotion in females. This study indicates that gender plays an important role in the sensitivity to MA during prenatal development and in adulthood.
本研究旨在比较雄性和雌性大鼠在成年期对亚慢性应用甲基苯丙胺（MA）的反应，这些大鼠在子宫内曾暴露于相同药物。通过 Laboras 仪器（荷兰 Metris B.V. 公司）连续五天，每天 1 小时，测试雄性和雌性大鼠在子宫内暴露于 5mg/kg MA 或生理盐水（SAL）后的自发性运动活动和探索行为。在测试前，使用 MA 1mg/kg 或 SAL 作为挑战。我们的结果表明，与子宫内暴露于 SAL 的大鼠相比，子宫内暴露于 MA 的大鼠对成年期的 MA 亚慢性给药更为敏感。然而，这种 MA 宫内暴露的敏化作用在雄性和雌性大鼠中表现不同。相比之下，MA 宫内暴露降低了雌性大鼠的基础运动。本研究表明，性别在产前发育和成年期对 MA 的敏感性中起着重要作用。
