Price B, Berner T, Henrich R T, Stewart J M, Moran E J
Price Associates, Inc., Washington DC, USA.
Regul Toxicol Pharmacol. 1996 Oct;24(2 Pt 1):171-6. doi: 10.1006/rtph.1996.0122.
A statistical analysis of the NIOSH (National Institute for Occupational Safety and Health) carbon disulfide (CS2) exposure database was conducted for purposes of establishing a benchmark concentration (BMC) for CS2. The analysis addressed the effects of CS2 exposure on the peripheral nervous system and on ischemic heart disease risk factors. The BMC is based on models relating response to exposure determined from statistical analysis of the continuous exposure data for individuals recorded in the NIOSH database. The results demonstrate that changes in the responses associated with increases in CS2 exposure at levels represented in the NIOSH database are relatively small after adjustment for confounders. The only response variables that had statistically significant relationships with CS2 were the peroneal nerve MCV (motor conduction velocity) and the peroneal nerve amplitude ratio. Based on these results, BMCs of 16.2 and 18.5 ppm were derived for MCV and amplitude ratio, respectively.
为了确定二硫化碳（CS2）的基准浓度（BMC），对美国国家职业安全与健康研究所（NIOSH）的二硫化碳暴露数据库进行了统计分析。该分析探讨了CS2暴露对外周神经系统和缺血性心脏病风险因素的影响。BMC基于通过对NIOSH数据库中记录的个体连续暴露数据进行统计分析确定的暴露与反应关系模型。结果表明，在对混杂因素进行调整后，NIOSH数据库中所代表的暴露水平下，与CS2暴露增加相关的反应变化相对较小。与CS2具有统计学显著关系的唯一反应变量是腓总神经运动传导速度（MCV）和腓总神经波幅比。基于这些结果，分别得出MCV和波幅比的BMC为16.2 ppm和18.5 ppm。
