Opacka J, Wrońska-Nofer T, Kołakowski J, Opalska B
Toxicol Lett. 1985 Feb-Mar;24(2-3):171-7. doi: 10.1016/0378-4274(85)90054-2.
The effect of chronic ethanol (EtOH) administration on CS2-induced peripheral neuropathy in rats was studied. Rats were exposed to 0.8 mg/l CS2 for 12-15 months and to 10% EtOH as only drink during the last 4 months of the experiment. Some biochemical correlates of Wallerian degeneration of the peripheral nerve were estimated and ultrastructural examinations of the peripheral nerves were performed. It was shown that EtOH augmented the alterations in lipid content provoked by CS2 in the peripheral nerves, i.e. an increase in cholesterol esters and in the ratio of cholesterol esters to free cholesterol (E/F ratio) and a decrease in phospholipid content. The magnitude of ultrastructural changes induced by CS2 in the nerves was increased by EtOH.
研究了长期给予乙醇（EtOH）对二硫化碳（CS2）诱导的大鼠周围神经病变的影响。大鼠暴露于0.8mg/l的CS2中12 - 15个月，并在实验的最后4个月仅饮用10%的EtOH作为饮品。评估了周围神经沃勒变性的一些生化相关性，并对周围神经进行了超微结构检查。结果表明，EtOH加剧了CS2引起的周围神经脂质含量变化，即胆固醇酯增加以及胆固醇酯与游离胆固醇的比例（E/F比）增加，磷脂含量降低。EtOH增加了CS2在神经中诱导的超微结构变化的程度。
