CNRS UMR 5228, Centre de Neurosciences Intégratives et Cognitives, Talence, France.
Science. 2012 Mar 23;335(6075):1510-3. doi: 10.1126/science.1207615. Epub 2012 Feb 23.
Posttraumatic stress disorder (PTSD) is characterized by a hypermnesia of the trauma and by a memory impairment that decreases the ability to restrict fear to the appropriate context. Infusion of glucocorticoids in the hippocampus after fear conditioning induces PTSD-like memory impairments and an altered pattern of neural activation in the hippocampal-amygdalar circuit. Mice become unable to identify the context as the correct predictor of the threat and show fear responses to a discrete cue not predicting the threat in normal conditions. These data demonstrate PTSD-like memory impairments in rodents and identify a potential pathophysiological mechanism of this condition.
创伤后应激障碍（PTSD）的特征是对创伤的过度记忆和记忆障碍，这会降低将恐惧限制在适当情境的能力。在恐惧条件作用后，将糖皮质激素注入海马体可引起类似 PTSD 的记忆障碍，并改变海马体-杏仁核回路中的神经激活模式。小鼠无法将情境识别为威胁的正确预测因子，并对正常情况下不会预测威胁的离散线索表现出恐惧反应。这些数据表明啮齿动物存在类似 PTSD 的记忆障碍，并确定了这种疾病的潜在病理生理机制。
