Bavovada R, Blaskó G, Shieh H L, Pezzuto J M, Cordell G A
Department of Pharmaceutical Botany, Chulalongkorn University, Bangkok, Thailand.
Planta Med. 1990 Aug;56(4):380-2. doi: 10.1055/s-2006-960988.
22-Hydroxytingenone was reisolated from a new source, Glyptopetalum sclerocarpum M. Laws and, for the first time, its unambiguous 13C-NMR assignments were accomplished through the use of APT, HETCOR, and selective INEPT spectroscopy. Intense, but nonspecific cytotoxic activity was observed when this substance was evaluated with a battery of cell lines comprised of the P-388 lymphocytic leukemia, KB carcinoma of the nasopharynx, and a number of human cancer cell types, i.e. HT-1080 fibrosarcoma, LU-1 lung cancer, COL-2 colon cancer, MEL-2 melanoma, and BC-1 breast cancer.
