Ngassapa O, Soejarto D D, Pezzuto J M, Farnsworth N R
Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago 60680.
J Nat Prod. 1994 Jan;57(1):1-8. doi: 10.1021/np50103a001.
Tingenone[1],20-hydroxy-20-epi-tingenone[2],celastrol[ 3], and salaspermic acid [4] have been isolated from Kokoona ochracea stem bark. The quinone-methide triterpenes 1-3 exhibited strong but non-specific in vitro cytotoxicity against P-388 murine lymphocytic leukemia cells and a panel of human cancer cell lines. Salaspermic acid [4] was not active in all the cancer cell lines used in this investigation. 13C-nmr spectra assignments for salaspermic acid have been accomplished through the application of 1D and 2D nmr spectral techniques, and 13C-nmr assignments for celastrol [3] have been revised.
