Paudel K R, Jaiswal A, Parajuli U, Bajracharya M
Department of Clinical Pharmacology, Kathmandu Medical College and Teaching Hospital (KMCTH), Kathmandu, Nepal.
Nepal Med Coll J. 2011 Jun;13(2):111-4.
Irrigation of root canals during endodontic therapy is an important step. Sodium hypochlorite (NaOCl), hydrogen peroxide (H2O2), chlorhexidine (CHX) and normal saline are commonly used intracanal irrigants to disinfect and clean the root canals. This prospective study was set to observe the efficacy of normal saline (0.9% NaCl) irrigation with sequential irrigation of 3% H2O2, 5.2% NaOCl and 0.9% NaCl. A total number of 228 dental patients were screened and 104 patients fulfilling the inclusion criteria were enrolled for the endodontic therapy of mature permanent teeth for the period of one year. Two treatment groups were constituted in which patients were randomly allocated equally in each treatment group. Post-obturation pain, swelling, analgesic use and eight weeks post-obturation radiological evaluation of the patients were carried out as the measurement of clinical and radiological success of the endodontic treatment. No statistically significant differences were observed in the measured treatment outcomes between two groups. However, studies involving larger sample size and longer post-obturation follow up are recommended for the further either confirmation or rejection of present findings.
根管治疗期间的根管冲洗是一个重要步骤。次氯酸钠（NaOCl）、过氧化氢（H2O2）、氯己定（CHX）和生理盐水是常用的根管内冲洗剂，用于消毒和清洁根管。本前瞻性研究旨在观察用3% H2O2、5.2% NaOCl和0.9% NaCl依次冲洗后，生理盐水（0.9% NaCl）冲洗的效果。共筛查了228名牙科患者，104名符合纳入标准的患者被纳入进行为期一年的成熟恒牙根管治疗。组成了两个治疗组，患者被随机平均分配到每个治疗组。对患者进行了根管充填后疼痛、肿胀、镇痛药使用情况以及根管充填后八周的影像学评估，作为根管治疗临床和影像学成功的衡量指标。两组间观察到的治疗结果无统计学显著差异。然而，建议进行样本量更大、根管充填后随访时间更长的研究，以进一步证实或否定目前的研究结果。
