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70 岁及 80 岁以上患者胸降主动脉瘤和胸腹主动脉瘤修复术后的生活质量和生存率。

Quality of life and survival of septuagenarians and octogenarians after repair of descending and thoracoabdominal aortic aneurysms.

机构信息

Department of Cardiothoracic Surgery, Mount Sinai School of Medicine, New York, NY, USA.

出版信息

J Thorac Cardiovasc Surg. 2013 Feb;145(2):378-84. doi: 10.1016/j.jtcvs.2012.01.068. Epub 2012 Feb 24.

Abstract

OBJECTIVE

We assessed quality of life and survival in elderly patients after complex aortic operations to aid in surgical decision making.

METHODS

A retrospective review was performed of 93 patients who underwent descending thoracic aneurysm or thoracoabdominal aortic aneurysm (TAAA) repair from 2002 to 2008. A Cox model was used for survival analysis. The SF-36 Item Health Survey was administered to assess postoperative quality of life in 39 patients and was compared with age- and gender-matched normal scores.

RESULTS

The mean age at operation was 75 ± 4.1 years; 51% of patients were male. In-hospital mortality was 15%. One-year survival was 69%, and 5-year survival was 45%. Only acute respiratory distress syndrome was a predictor of in-hospital mortality (hazard ratio = 3.75; P < .01) and 1-year mortality (hazard ratio = 4.61; P < .001). After 1 year, patients enjoyed longevity equivalent to that of a normal age- and gender-matched population (standardized mortality ratio = 1.06; P = .81). Being male is a predictor of long-term survival (hazard ratio = 0.18; P < .05). For women, extremely low and high body mass indexes (quadratic term = 0.020; P < .05) with an inflection point of body mass index of 28 is a risk factor of long-term survival. Quality of life scores were similar to those of the general population except for lower vitality scores, (s-score = -0.67, 95% CI, -1.09 to -0.26).

CONCLUSIONS

TAAA repair in this selected older surgical population yields acceptable survival beyond the first year. Among 1-year survivors, quality of life is similar to that of an age- and gender-matched population.

摘要

目的

评估老年患者接受复杂主动脉手术后的生活质量和生存情况,以辅助手术决策。

方法

回顾性分析了 2002 年至 2008 年间接受降胸主动脉瘤或胸腹主动脉瘤(TAAA)修复术的 93 例患者。采用 Cox 模型进行生存分析。对 39 例患者进行了 SF-36 项目健康调查,以评估术后生活质量,并与年龄和性别匹配的正常评分进行比较。

结果

手术时的平均年龄为 75 ± 4.1 岁;51%的患者为男性。院内死亡率为 15%。1 年生存率为 69%,5 年生存率为 45%。只有急性呼吸窘迫综合征是院内死亡率(危险比=3.75;P<.01)和 1 年死亡率(危险比=4.61;P<.001)的预测因素。1 年后,患者的寿命与年龄和性别匹配的正常人群相当(标准化死亡率比=1.06;P=.81)。男性是长期生存的预测因素(危险比=0.18;P<.05)。对于女性,极低和极高的体重指数(二次项=0.020;P<.05),体重指数的拐点为 28,是长期生存的危险因素。生活质量评分与普通人群相似,除了活力评分较低(s 评分=-0.67,95%置信区间,-1.09 至-0.26)。

结论

在这一选择的老年手术人群中,TAAA 修复术在第一年之后可获得可接受的生存率。在 1 年幸存者中,生活质量与年龄和性别匹配的人群相似。

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