Department of Cardiothoracic Surgery, Mount Sinai School of Medicine, New York, NY, USA.
J Thorac Cardiovasc Surg. 2013 Feb;145(2):378-84. doi: 10.1016/j.jtcvs.2012.01.068. Epub 2012 Feb 24.
We assessed quality of life and survival in elderly patients after complex aortic operations to aid in surgical decision making.
A retrospective review was performed of 93 patients who underwent descending thoracic aneurysm or thoracoabdominal aortic aneurysm (TAAA) repair from 2002 to 2008. A Cox model was used for survival analysis. The SF-36 Item Health Survey was administered to assess postoperative quality of life in 39 patients and was compared with age- and gender-matched normal scores.
The mean age at operation was 75 ± 4.1 years; 51% of patients were male. In-hospital mortality was 15%. One-year survival was 69%, and 5-year survival was 45%. Only acute respiratory distress syndrome was a predictor of in-hospital mortality (hazard ratio = 3.75; P < .01) and 1-year mortality (hazard ratio = 4.61; P < .001). After 1 year, patients enjoyed longevity equivalent to that of a normal age- and gender-matched population (standardized mortality ratio = 1.06; P = .81). Being male is a predictor of long-term survival (hazard ratio = 0.18; P < .05). For women, extremely low and high body mass indexes (quadratic term = 0.020; P < .05) with an inflection point of body mass index of 28 is a risk factor of long-term survival. Quality of life scores were similar to those of the general population except for lower vitality scores, (s-score = -0.67, 95% CI, -1.09 to -0.26).
TAAA repair in this selected older surgical population yields acceptable survival beyond the first year. Among 1-year survivors, quality of life is similar to that of an age- and gender-matched population.
评估老年患者接受复杂主动脉手术后的生活质量和生存情况,以辅助手术决策。
回顾性分析了 2002 年至 2008 年间接受降胸主动脉瘤或胸腹主动脉瘤(TAAA)修复术的 93 例患者。采用 Cox 模型进行生存分析。对 39 例患者进行了 SF-36 项目健康调查,以评估术后生活质量,并与年龄和性别匹配的正常评分进行比较。
手术时的平均年龄为 75 ± 4.1 岁;51%的患者为男性。院内死亡率为 15%。1 年生存率为 69%,5 年生存率为 45%。只有急性呼吸窘迫综合征是院内死亡率(危险比=3.75;P<.01)和 1 年死亡率(危险比=4.61;P<.001)的预测因素。1 年后,患者的寿命与年龄和性别匹配的正常人群相当(标准化死亡率比=1.06;P=.81)。男性是长期生存的预测因素(危险比=0.18;P<.05)。对于女性,极低和极高的体重指数(二次项=0.020;P<.05),体重指数的拐点为 28,是长期生存的危险因素。生活质量评分与普通人群相似,除了活力评分较低(s 评分=-0.67,95%置信区间,-1.09 至-0.26)。
在这一选择的老年手术人群中,TAAA 修复术在第一年之后可获得可接受的生存率。在 1 年幸存者中,生活质量与年龄和性别匹配的人群相似。