Centre for Human and Clinical Genetics, Leiden University Medical Centre, Leiden, The Netherlands.
Crit Rev Oncol Hematol. 2012 Sep;83(3):329-40. doi: 10.1016/j.critrevonc.2012.01.004. Epub 2012 Feb 25.
Individuals at risk for developing hereditary cancer are offered surveillance in order to improve the prognosis. An important question is whether the benefit of surveillance outweighs the psychological burden. In this review, we evaluated all studies that investigated psychological distress and the quality of life in individuals under surveillance for hereditary cancer of the breast, ovarian, prostate, pancreas, colorectum, melanoma, and various rare syndromes such as familial adenomatous polyposis, Li-Fraumeni and Peutz-Jeghers syndrome. Thirty-two studies were identified. Surveillance for most hereditary cancers was associated with good psychological outcomes. However, surveillance of individuals at high risk for developing multiple tumors appeared to be associated with increased distress and a lower quality of life. Common factors associated with worse psychological outcomes included a personal history of cancer, female gender, having a first degree relative with cancer, negative illness perceptions and coping style. The use of a simple screening tool to identify distressed individuals is recommended.
个体存在遗传性癌症发病风险时，通常会接受监测，以改善预后。一个重要的问题是监测的益处是否超过心理负担。在本次综述中，我们评估了所有研究遗传性乳腺癌、卵巢癌、前列腺癌、胰腺癌、结直肠癌、黑色素瘤以及家族性腺瘤性息肉病、Li-Fraumeni 和 Peutz-Jeghers 综合征等各种罕见综合征个体的心理困扰和生活质量。共确定了 32 项研究。大多数遗传性癌症的监测与良好的心理结局相关。然而，监测有发生多种肿瘤风险的个体似乎与更多的困扰和更低的生活质量相关。与更差的心理结局相关的常见因素包括癌症个人史、女性、一级亲属患有癌症、负面的疾病认知和应对方式。建议使用简单的筛查工具来识别受困扰的个体。
