Department of Food Microbiology, Central Food Technological Research Institute-CFTRI, Council of Scientific and Industrial Research-CSIR, Mysore 570020, India.
Int J Toxicol. 2012 Mar;31(2):158-65. doi: 10.1177/1091581811430402. Epub 2012 Feb 24.
In a pharmacokinetic study, high-performance liquid chromatography analysis of blood samples of Wistar female rats fed with partially saturated canthaxanthin (PSC) of Aspergillus carbonarius showed the presence of the carotenoid in the plasma within 6 hours of feeding. In another study for safety assessment of PSC fed to rats over a period of 28 days at 0.05%, 0.10%, and 0.25%, the rats showed no changes in food intake. There were no significant differences observed in body weight, hematological parameters, or serum clinical enzymes compared to the control group not fed with PSC. Deposition of PSC in the eyes of the rats was also not observed. The results showed that PSC-fed rats were not adversely affected as far as toxicological studies were concerned.
在一项药代动力学研究中，对喂食黄粉虫蛹来源的部分饱和角黄素（PSC）的 Wistar 雌性大鼠的血液样本进行高效液相色谱分析，结果表明在喂食后 6 小时内血浆中存在类胡萝卜素。在另一项为期 28 天、以 0.05%、0.10%和 0.25%的剂量向大鼠喂食 PSC 的安全性评估研究中，与未喂食 PSC 的对照组相比，大鼠的食物摄入量没有变化。与对照组相比，体重、血液学参数或血清临床酶均无显著差异。也未观察到 PSC 在大鼠眼睛中的沉积。结果表明，就毒理学研究而言，喂食 PSC 的大鼠没有受到不利影响。
