Department of Food Microbiology, Central Food Technological Research Institute (Council of Scientific and Industrial Research), Mysore 570020, India.
Food Chem Toxicol. 2011 Dec;49(12):3098-103. doi: 10.1016/j.fct.2011.09.003. Epub 2011 Sep 8.
Effect of feeding partially saturated canthaxanthin (PSC), purified from Aspergillus carbonarius mutant, was studied using four groups of female albino rats (n=6) for 4 weeks. While the control group received basal diet ad libitum, Groups I, II and III were fed with basal diet containing 50, 100 and 250 ppm PSC, respectively. PSC feeding did not cause any significant changes in food intake and there was no gain in body weight either. PSC included in the diet significantly decreased cholesterol in blood. There was 44.75% and 60.54% decrease in LDL-cholesterol in rats fed with 50 and 100 ppm carotenoid. Hepatic ascorbic acid content increased by 44.59% in rats fed with 50 ppm PSC. Dietary PSC at 250 ppm lowered lipid peroxides by 19.49%. Activities of antioxidant enzymes, glutathione transferase and catalase were significantly higher in serum and liver of PSC fed rats compared to the controls. The results suggested that PSC feeding can induce hypocholesterolmic and antioxidant properties in rats.
用 4 组雌性白化大鼠（每组 6 只）进行了 4 周的实验，研究了从曲霉菌突变株中提取的部分饱和角黄素（PSC）喂养的效果。对照组自由喂食基础饲料，第 I、II 和 III 组分别喂食含 50、100 和 250ppm PSC 的基础饲料。PSC 喂养没有引起食物摄入量的任何显著变化，体重也没有增加。PSC 包含在饮食中可显著降低血液中的胆固醇。喂食 50 和 100ppm 类胡萝卜素的大鼠的 LDL-胆固醇分别降低了 44.75%和 60.54%。喂食 50ppm PSC 的大鼠肝内抗坏血酸含量增加了 44.59%。饮食 PSC 可使 250ppm 的脂质过氧化物降低 19.49%。与对照组相比，PSC 喂养的大鼠血清和肝脏中的抗氧化酶、谷胱甘肽转移酶和过氧化氢酶的活性显著升高。结果表明，PSC 喂养可诱导大鼠产生降胆固醇和抗氧化特性。
