Kwak Sungjong, Brief Elana, Langlais Denis, Kitson Neil, Lafleur Michel, Thewalt Jenifer
Department of Chemistry, Center for Self-Assembled Chemical Structures (CSACS), Université de Montréal, C.P. 6128, Succ. Centre Ville, Montréal, Québec, Canada H3C 3J7.
Biochim Biophys Acta. 2012 May;1818(5):1410-9. doi: 10.1016/j.bbamem.2012.02.013. Epub 2012 Feb 16.
Ethanol is used in a variety of topical products. It is known to enhance the permeability of the skin by altering the ability of the stratum corneum (SC) intercellular membranes to form an effective barrier. In addition, ethanol and other alcohols are key components of antiseptic gels currently used for hand wash. Using infrared and deuterium NMR spectroscopy as well as calorimetry, we have investigated the effect of ethanol on a model membrane composed of lipids representing the three classes of SC lipids, an equimolar mixture of N-palmitoylsphingosine (ceramide), palmitic acid and cholesterol. Ethanol is found to influence the membrane in a dose dependent manner, disrupting packing and increasing lipid motion at low concentrations and selectively extracting lipids at moderate concentrations.
乙醇被用于多种局部用产品中。已知它可通过改变角质层（SC）细胞间膜形成有效屏障的能力来增强皮肤的通透性。此外，乙醇和其他醇类是目前用于洗手的抗菌凝胶的关键成分。我们使用红外光谱、氘核磁共振光谱以及量热法，研究了乙醇对由代表SC三类脂质的脂质组成的模型膜的影响，该模型膜为N-棕榈酰鞘氨醇（神经酰胺）、棕榈酸和胆固醇的等摩尔混合物。发现乙醇以剂量依赖的方式影响该膜，在低浓度下破坏堆积并增加脂质运动，在中等浓度下选择性地提取脂质。
