Department of Ophthalmology, Ajou University School of Medicine, Suwon, Korea.
J Glaucoma. 2012 Dec;21(9):596-600. doi: 10.1097/IJG.0b013e31824cfbf7.
To investigate the relationship between central visual field (VF) defects and ocular pulse amplitude (OPA) in early normal-tension glaucoma (NTG).
This retrospective study included 100 eyes of 100 subjects: 54 NTG patients whose mean deviations were better than -7.00 dB and 46 normal subjects. OPA was measured by dynamic contour tonometry. NTG patients were divided into 2 subgroups according to VF tests: the central VF-invading and the central VF-sparing groups. Ocular parameters including OPA, intraocular pressure (IOP), and indices of VF tests were analyzed in glaucoma patients and normal subjects.
There was no difference in the OPA between the NTG and normal groups. However, IOP and OPA of the central VF-invading group (14.4 ± 2.87 and 2.9 ± 0.78 mm Hg) were higher than those of the central VF-sparing group (12.7 ± 2.52 and 2.0 ± 0.80 mm Hg; P = 0.025 and P < 0.001, respectively). OPA, but not IOP, showed a positive correlation with the VF test indices that represented central field defects (r = 0.494, P < 0.001).
Increased OPA was related to more centrally located VF defects in NTG patients with mild VF defects.
研究早期正常眼压性青光眼（NTG）中心视野缺损与眼脉冲振幅（OPA）之间的关系。
本回顾性研究共纳入 100 只眼 100 例患者：54 例平均偏差>-7.00 dB 的 NTG 患者和 46 例正常对照者。采用动态轮廓眼压计测量 OPA。根据视野检查结果，将 NTG 患者分为中心视野侵犯组和中心视野保留组。分析青光眼患者和正常对照者的眼参数，包括 OPA、眼压（IOP）和视野检查指数。
NTG 组和正常组之间的 OPA 无差异。然而，中心视野侵犯组的 IOP 和 OPA（14.4±2.87 和 2.9±0.78 mmHg）高于中心视野保留组（12.7±2.52 和 2.0±0.80 mmHg；P=0.025 和 P<0.001）。OPA 而非 IOP 与代表中心视野缺损的视野检查指数呈正相关（r=0.494，P<0.001）。
在具有轻度视野缺损的 NTG 患者中，OPA 增加与更靠近中心的视野缺损有关。
