播散性神经母细胞瘤婴儿骨髓的细胞形态学评估
Cyto-morphologic evaluation of bone marrow in infants with disseminated neuroblastoma.
作者信息
Sorrentino Stefania, Rosanda Cristina, Parodi Stefano, Rita Gigliotti Anna, Pasino Mirella, Defferrari Raffaella, Tonini Gian Paolo, De Bernardi Bruno
机构信息
Department of Haematology-Oncology, Giannina Gaslini Children's Hospital, National Cancer Research Institute, Genova, Italy.
出版信息
J Pediatr Hematol Oncol. 2012 Mar;34(2):154-8. doi: 10.1097/MPH.0b013e31821d80be.
We studied the prevalence and degree of tumor cell infiltration (TCI) in bone marrow (BM) aspirates of 89 infants with stage 4/4 S neuroblastoma and correlated them with MYCN gene status and patient outcome. TCI was scored 0, +, ++, and +++, the last corresponding to an infiltration greater than 10%. TCI 0 was more frequent in stage 4 than in stage 4 S. TCI + and ++ were equally represented. TCI +++ was found only in 9 patients, all with typical stage 4 features (bone or lung involvement). Overall survival was not significantly influenced by the presence and degree of TCI.
我们研究了89例4/4S期神经母细胞瘤婴儿骨髓穿刺液中肿瘤细胞浸润（TCI）的发生率和程度，并将其与MYCN基因状态及患者预后相关联。TCI分为0、+、++和+++四级，最后一级对应浸润大于10%。TCI为0级在4期比4S期更常见。TCI为+和++级的比例相同。仅在9例患者中发现TCI为+++级，所有这些患者均具有典型的4期特征（骨或肺受累）。TCI的存在及程度对总生存期无显著影响。
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