Sorrentino Stefania, Rosanda Cristina, Parodi Stefano, Rita Gigliotti Anna, Pasino Mirella, Defferrari Raffaella, Tonini Gian Paolo, De Bernardi Bruno
Department of Haematology-Oncology, Giannina Gaslini Children's Hospital, National Cancer Research Institute, Genova, Italy.
J Pediatr Hematol Oncol. 2012 Mar;34(2):154-8. doi: 10.1097/MPH.0b013e31821d80be.
We studied the prevalence and degree of tumor cell infiltration (TCI) in bone marrow (BM) aspirates of 89 infants with stage 4/4 S neuroblastoma and correlated them with MYCN gene status and patient outcome. TCI was scored 0, +, ++, and +++, the last corresponding to an infiltration greater than 10%. TCI 0 was more frequent in stage 4 than in stage 4 S. TCI + and ++ were equally represented. TCI +++ was found only in 9 patients, all with typical stage 4 features (bone or lung involvement). Overall survival was not significantly influenced by the presence and degree of TCI.
我们研究了89例4/4S期神经母细胞瘤婴儿骨髓穿刺液中肿瘤细胞浸润（TCI）的发生率和程度，并将其与MYCN基因状态及患者预后相关联。TCI分为0、+、++和+++四级，最后一级对应浸润大于10%。TCI为0级在4期比4S期更常见。TCI为+和++级的比例相同。仅在9例患者中发现TCI为+++级，所有这些患者均具有典型的4期特征（骨或肺受累）。TCI的存在及程度对总生存期无显著影响。
