Department of Neurosurgery, Severance Hospital, Brain Korea 21 Project for Medical Science, Brain Research Institute, Yonsei University College of Medicine, Seodaemun-Gu, Seoul, Republic of Korea.
Acta Neurochir (Wien). 2012 May;154(5):823-30. doi: 10.1007/s00701-012-1306-4. Epub 2012 Feb 27.
The aim was to assess the effect of deep brain stimulation for secondary hemidystonias associated with focal post-traumatic brain injuries.
Four patients underwent deep brain stimulation for the treatment of medically refractory secondary hemidystonia associated with post-traumatic brain injury. Clinical outcome assessments were based on Burke-Fahn-Marsden Dystonia Rating Scale movement and disability scores. Health-related quality of life was assessed using a 36-item short-form general health survey questionnaire administered preoperatively and at the last follow-up visit.
Burke-Fahn-Marsden Dystonia Rating Scale movement scores had improved by 73.2% (range, 38.1-94.1) and disability scores had improved by 75% (range, 60-100) at the 2-year follow-up visit. The health-related quality of life assessment revealed satisfactory results at follow-up, such that body pain, general health, vitality, social functioning, as well as emotional and mental health improved significantly.
Globus pallidus internus deep brain stimulation can be used to modulate and ameliorate secondary hemidystonia associated with focal post-traumatic brain injury.
本研究旨在评估深部脑刺激对继发于局灶性创伤性脑损伤的偏侧舞蹈症的疗效。
4 例患者因药物难治性继发于创伤性脑损伤的偏侧舞蹈症接受深部脑刺激治疗。临床疗效评估基于 Burke-Fahn-Marsden 肌张力障碍评定量表的运动和残疾评分。采用 36 项简明健康调查问卷（SF-36）评估健康相关生活质量，在术前和末次随访时进行评估。
在 2 年随访时，Burke-Fahn-Marsden 肌张力障碍评定量表的运动评分改善了 73.2%（范围，38.1-94.1），残疾评分改善了 75%（范围，60-100）。健康相关生活质量评估显示随访时结果令人满意，身体疼痛、一般健康、活力、社会功能以及情绪和心理健康均显著改善。
苍白球内侧核深部脑刺激可用于调节和改善继发于局灶性创伤性脑损伤的偏侧舞蹈症。
