Lang Pierre Olivier, Govind Sheila, Aspinall Richard
Department of Internal Medicine, Rehabilitation and Geriatrics, Medical School and University Hospitals of Geneva, Hospital of Trois-Chêne, Chemin du Pont-Bochet 3, CH-1226, Thônex, Geneva, Switzerland.
Age (Dordr). 2013 Jun;35(3):609-20. doi: 10.1007/s11357-012-9393-y. Epub 2012 Feb 26.
Immunosenescence is the term commonly used to describe the multifaceted phenomenon encompassing all changes occurring in the immune system during aging. It contributes to render older adults more prone to develop infectious disease and main age-related diseases. While age clearly imposes drastic changes in immune physiology, older adults have heterogeneous health and immune phenotypes. This confronts scientists and researcher to develop more age-specific interventions rather than simply adopting intervention regimes used in younger people and this in order to maintain immune protection in older adults. Thus, this review provides evidences of the central role played by cell-mediated immunity in the immunosenescence process and explores the means by which senescent state of the cell-mediated immune function could be identified and predicted using biomarkers. Furthermore considerations are given to recent advances made in the field of age-specific immune interventions that could contribute to maintain immune protection, to improve quality of life, and/or to promote healthy aging of the growing part of the population.
免疫衰老这一术语通常用于描述涵盖衰老过程中免疫系统发生的所有变化的多方面现象。它促使老年人更易患传染病和主要的年龄相关疾病。虽然年龄显然会给免疫生理学带来巨大变化，但老年人具有不同的健康和免疫表型。这使科学家和研究人员面临开发更具年龄特异性的干预措施的挑战，而不是简单地采用针对年轻人的干预方案，以便在老年人中维持免疫保护。因此，本综述提供了细胞介导免疫在免疫衰老过程中所起核心作用的证据，并探讨了利用生物标志物识别和预测细胞介导免疫功能衰老状态的方法。此外，还考虑了年龄特异性免疫干预领域的最新进展，这些进展有助于维持免疫保护、改善生活质量和/或促进不断增长的老年人口的健康衰老。
