Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Head Neck. 2013 Mar;35(3):321-8. doi: 10.1002/hed.22961. Epub 2012 Feb 24.
The local-regional failure of advanced oral squamous cell carcinoma (OSCC) after surgery results from the regrowth of residual tumor cells that may be stimulated by epidermal growth factor receptor (EGFR) ligands during the wound healing process.
The level of EGFR ligands in human drain fluids (DFs) from OSCC resection and remote flap donor site were determined. A mouse model of microscopic residual OSCC was established and treated with cetuximab to measure tumor growth, survival, and cervical lymph node metastases. A mouse model of wound healing was also established to assess the effect of an EGFR antibody on the wound healing process.
EGFR ligands are found in sites from OSCC resection. EGFR targeted therapy can delay tumor regrowth in a microscopic residual disease model of OSCC without significant effects on local wound healing.
These results provide a strong rationale for clinical evaluation of this approach to treat patients with local-regionally advanced OSCC.
手术后晚期口腔鳞状细胞癌（OSCC）的局部区域复发是由于残留肿瘤细胞的再生，这些细胞可能在伤口愈合过程中受到表皮生长因子受体（EGFR）配体的刺激。
检测了 OSCC 切除和游离皮瓣供区人引流液（DF）中 EGFR 配体的水平。建立了微小残留 OSCC 的小鼠模型，并使用西妥昔单抗进行治疗，以测量肿瘤生长、存活和颈部淋巴结转移。还建立了一个伤口愈合模型，以评估 EGFR 抗体对伤口愈合过程的影响。
在 OSCC 切除部位发现了 EGFR 配体。EGFR 靶向治疗可延缓微小残留 OSCC 疾病模型中的肿瘤再生，而对局部伤口愈合无明显影响。
这些结果为临床评估该方法治疗局部区域晚期 OSCC 患者提供了强有力的依据。
