Zhou Jun-Jie, Feng Yan-Chuan, Zhao Min-Long, Guo Qi, Zhao Xi-Bo
The Stomatological Hospital, Anyang Sixth People's Hospital, Anyang, China.
Front Bioeng Biotechnol. 2025 Mar 27;13:1566522. doi: 10.3389/fbioe.2025.1566522. eCollection 2025.
Head and neck cancer (HNC) critically affects patient survival and quality of life, highlighting the need for optimized perioperative interventions. While conventional therapies face limitations in specificity and toxicity, nanotechnology has emerged as a revolutionary approach. Preoperative application of tumor-targeting nanoprobes enables molecular-level lesion identification biomarker-specific conjugation and spatially resolved fluorescence quantification. Intraoperatively, fluorescent nanomaterials enhance surgical precision through selective tumor accumulation, delineating malignant margins in real time. Postoperatively, engineered nanocarriers improve therapeutic outcomes by delivering drugs with spatial control, minimizing off-target effects, and enabling multimodal synergies. These nanotechnology-driven strategies collectively address critical challenges in HNC management, including diagnostic sensitivity, intraoperative visualization, and postoperative recurrence. Their inherent advantages-precision targeting, reduced systemic toxicity, and multifunctional integration-establish them as cornerstone tools in modern oncology. Future advancements in nanomaterial design and biocompatibility are poised to further refine therapeutic efficacy, survival rates, and patient-centered outcomes.
头颈癌严重影响患者的生存率和生活质量，凸显了优化围手术期干预措施的必要性。虽然传统疗法在特异性和毒性方面存在局限性，但纳米技术已成为一种革命性的方法。术前应用肿瘤靶向纳米探针能够实现分子水平的病变识别、生物标志物特异性结合以及空间分辨荧光定量。术中，荧光纳米材料通过选择性肿瘤聚集提高手术精度，实时勾勒出恶性边缘。术后，工程纳米载体通过空间控制给药、将脱靶效应降至最低并实现多模式协同作用来改善治疗效果。这些由纳米技术驱动的策略共同应对了头颈癌管理中的关键挑战，包括诊断敏感性、术中可视化和术后复发。它们固有的优势——精准靶向、降低全身毒性和多功能整合——使其成为现代肿瘤学的基石工具。纳米材料设计和生物相容性方面的未来进展有望进一步提高治疗效果、生存率和以患者为中心的治疗结果。
