Pandit Nymphea, Malik Rajvir, Philips Deepa
Department of Periodontics and Oral Implantology, D.A.V (C) Dental College and Hospital, Yamuna Nagar, Haryana, India.
J Indian Soc Periodontol. 2011 Oct;15(4):328-37. doi: 10.4103/0972-124X.92564.
Tissue engineering is a highly promising field of reconstructive biology that draws on recent advances in medicine, surgery, molecular and cellular biology, polymer chemistry, and physiology. The objective of using tissue engineering as therapeutic application has been to harness its ability to exploit selected and primed cells together with an appropriate mix of regulatory factors, to allow growth and specialization of cells and matrix. The authors reviewed controlled clinical trials which also included histological studies that evaluated the potential of tissue engineering as a clinical tool in regeneration. PubMed/MEDLINE databases were searched for studies up to and including June 2010 to identify appropriate articles. A comprehensive search was designed, and the articles were independently screened for eligibility. Articles with authentic controls and proper randomization and pertaining specifically to their role in periodontal regeneration were included. Studies demonstrated that the periodontal regeneration with the use of combination of tissue engineered products with an osteoconductive matrix improve the beneficial effect of these materials by accelerating cellular in growth and revascularization of the wound site. Studies have suggested the use of rh Platelet-derived growth factor + beta tricalcium phosphate for regeneration of the periodontal attachment apparatus in combination with collagen membranes as an acceptable alternative to connective tissue graft for covering gingival recession defects. The studies concluded that growth factors promote true regeneration of the periodontal attachment apparatus and the use of combination protein therapeutics which is commercially available can provide more predictable, faster, less invasive, less traumatic, and efficient outcome for the patient.
组织工程是重建生物学中一个极具前景的领域，它借鉴了医学、外科、分子与细胞生物学、高分子化学和生理学等领域的最新进展。将组织工程用作治疗手段的目的是利用其能力，将经过选择和预处理的细胞与适当组合的调节因子相结合，以促进细胞和基质的生长与分化。作者回顾了对照临床试验，其中还包括组织学研究，这些研究评估了组织工程作为再生临床工具的潜力。在PubMed/MEDLINE数据库中检索截至2010年6月（包括该月）的研究，以确定合适的文章。设计了全面的检索策略，并对文章进行独立筛选以确定其是否符合要求。纳入具有真实对照和适当随机分组且专门涉及它们在牙周再生中作用的文章。研究表明，使用组织工程产品与骨传导基质的组合进行牙周再生，通过加速细胞向内生长和伤口部位的血管生成，可提高这些材料的有益效果。研究建议使用重组血小板衍生生长因子+β-磷酸三钙联合胶原膜来再生牙周附着装置，作为覆盖牙龈退缩缺损的结缔组织移植的可接受替代方法。研究得出结论，生长因子可促进牙周附着装置的真正再生，使用市售的组合蛋白疗法可为患者提供更可预测、更快、侵入性更小、创伤更小且更有效的治疗结果。
