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抗血管内皮生长因子疗法治疗与视盘玻璃疣相关的双侧脉络膜新生血管化

Bilateral choroidal neovascularization associated with optic nerve head drusen treated by antivascular endothelial growth factor therapy.

作者信息

Delas Barbara, Almudí Lorena, Carreras Anabel, Asaad Mouafk

机构信息

Ophthalmology Service, Hospital de Terrassa, Barcelona, Spain.

出版信息

Clin Ophthalmol. 2012;6:225-30. doi: 10.2147/OPTH.S22991. Epub 2012 Feb 13.

DOI:10.2147/OPTH.S22991
PMID:22368440
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3284202/
Abstract

OBJECTIVE

To report a good clinical outcome in a patient with bilateral choroidal neovascularization (CNV) associated with optic nerve head drusen (ONHD) treated with intravitreal ranibizumab injection.

METHODS

A 12-year-old girl was referred for loss of right eye vision detected in a routine check-up. Best-corrected visual acuity (BCVA) was hand movements in the right eye and 0.9 in the left eye. Funduscopy revealed the presence of superficial and buried bilateral ONHD, which was confirmed by ultrasonography and computed tomography, and the study was completed with perimetry. The presence of bilateral CNV, active in the right eye, was observed and subsequently confirmed using fluorescein angiography and optical coherence tomography.

RESULTS

Treatment with two consecutive injections of intravitreal ranibizumab resulted in inactivation of the neovascular membrane with subretinal fluid reabsorption and improved right eye BCVA. After 12 months' follow-up, this was 20/60 and stable.

CONCLUSION

Although there are no published studies of safety in children, antiangiogenic therapy for CNV secondary to ONHD may be useful and safe. A search of the literature produced only one previously reported case of ONHD-associated CNV treated with antivascular endothelial growth factor alone.

摘要

目的

报告玻璃体内注射雷珠单抗治疗与视盘小凹（ONHD）相关的双侧脉络膜新生血管（CNV）患者取得良好临床疗效的情况。

方法

一名12岁女孩因在常规检查中发现右眼视力丧失前来就诊。右眼最佳矫正视力（BCVA）为手动，左眼为0.9。眼底检查发现双侧存在浅表和埋藏性ONHD，经超声检查和计算机断层扫描证实，并用视野检查完成了该研究。观察到双侧CNV的存在，右眼为活动性，随后经荧光素血管造影和光学相干断层扫描证实。

结果

连续两次玻璃体内注射雷珠单抗治疗导致新生血管膜失活，视网膜下液吸收，右眼BCVA改善。随访12个月后，视力为20/60且稳定。

结论

虽然尚无关于儿童安全性的已发表研究，但抗血管生成疗法用于治疗ONHD继发的CNV可能是有用且安全的。文献检索仅发现1例先前报道的单独使用抗血管内皮生长因子治疗ONHD相关CNV的病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de43/3284202/4907c11f865a/opth-6-225f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de43/3284202/1f9a211c9883/opth-6-225f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de43/3284202/31f50e0ee344/opth-6-225f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de43/3284202/878f53d67797/opth-6-225f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de43/3284202/2826902806f0/opth-6-225f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de43/3284202/ec11004a54c8/opth-6-225f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de43/3284202/500a5324b398/opth-6-225f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de43/3284202/289d3fa7de3e/opth-6-225f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de43/3284202/4907c11f865a/opth-6-225f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de43/3284202/1f9a211c9883/opth-6-225f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de43/3284202/31f50e0ee344/opth-6-225f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de43/3284202/878f53d67797/opth-6-225f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de43/3284202/2826902806f0/opth-6-225f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de43/3284202/ec11004a54c8/opth-6-225f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de43/3284202/500a5324b398/opth-6-225f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de43/3284202/289d3fa7de3e/opth-6-225f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de43/3284202/4907c11f865a/opth-6-225f8.jpg

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1
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J AAPOS. 2011 Feb;15(1):87-90. doi: 10.1016/j.jaapos.2010.10.011.
2
Successful Treatment of Subretinal Neovascularization with Intravitreal Ranibizumab in a Child with Optic Nerve Head Drusen.玻璃体内注射雷珠单抗成功治疗一名患有视乳头玻璃疣儿童的视网膜下新生血管化
J Pediatr Ophthalmol Strabismus. 2009 Aug 21. doi: 10.3928/01913913-20090818-03.
3
The effects of intravitreal bevacizumab on patients with macular edema secondary to branch retinal vein occlusion.
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Rom J Ophthalmol. 2019 Jan-Mar;63(1):75-85.
4
Paediatric case of peripapillary choroidal neovascularisation associated with optic disc drusen treated with aflibercept.阿柏西普治疗与视盘玻璃膜疣相关的视乳头周围脉络膜新生血管的儿科病例。
BMJ Case Rep. 2019 Jan 14;12(1):bcr-2018-228134. doi: 10.1136/bcr-2018-228134.
5
Optic Nerve Head Drusen: An Update.视神经乳头 drusen：最新进展。 （注：这里“drusen”一般译为“玻璃膜疣”，但直接保留原文未翻译，因为不太明确其在特定语境下是否有特殊含义或需要特别处理。）
Neuroophthalmology. 2018 Apr 25;42(6):367-384. doi: 10.1080/01658107.2018.1444060. eCollection 2018 Dec.
6
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4
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6
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7
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Br J Ophthalmol. 2005 Nov;89(11):1522-8. doi: 10.1136/bjo.2005.074716.
8
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9
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