Bianca S, Ettore G
Registro Siciliano Malformazioni Congenite.
Images Paediatr Cardiol. 2001 Jul;3(3):10-4.
A significant bias in sex ratio has been documented for several congenital cardiac malformations. Transposition of the great arteries has been associated with a such a bias but no explanation has been proposed for this bias. We evaluated 95 isolated livebirths with transposition of the great arteries cases referred to the Sicilian Registry of Congenital Malformations from 1991 to 1998. We found a statistically significant male bias of 2.8 and this was significantly associated with both maternal and paternal occupational exposure to agricultural chemicals for male infants with transposition, but not for female infants. This study raises new questions about the possible role played by environmental chemicals in relationship to birth defects and to sex ratio imbalance.
已有文献记载，几种先天性心脏畸形存在显著的性别比例偏差。大动脉转位与这种偏差有关，但尚未对这种偏差提出解释。我们评估了1991年至1998年转诊至西西里先天性畸形登记处的95例孤立存活的大动脉转位病例。我们发现，男性偏差具有统计学意义，为2.8，这与大动脉转位男婴的母亲和父亲职业性接触农用化学品显著相关，但与女婴无关。这项研究就环境化学物质在出生缺陷和性别比例失衡方面可能发挥的作用提出了新问题。
