Department of Cardiac Sciences, Ministry of National Guard Health Affairs, Riyadh, Kingdom of Saudi Arabia. E-mail.
Saudi Med J. 2020 Oct;41(10):1054-1062. doi: 10.15537/smj.2020.10.25418.
To assess potential risk factors and their effect on the development of transposition of the great arteries (TGA). Methods: A retrospective case-control study of all patients diagnosed with TGA between 1999 to 2016 at King Abdulaziz Medical City, Riyadh, Saudi Arabia. Age and gender-matched controls were selected. Risk factors, including consanguinity, gestational diabetes, family history of congenital heart disease, parental age, and maternal parity, were collected. Regression modeling was used to analyze the effects of risk factors on the development of TGA. Results: A total of 206 patients with transposition of the great arteries were enrolled in the study. Transposition of the great arteries cases were divided into simple and complex TGA. Selected healthy controls were 446. In the studied cases, consanguinity was found in 95 (46%) of cases, gestational diabetes was diagnosed in 36 (17.5%) mothers, and 35 (17%) had a confirmed family history of congenital heart disease. When risk factors of the cases were compared to the controls, consanguinity, gestational diabetes, maternal age, and parity were found to significantly increase the incidence of TGA. Conclusion: Our study revealed significant risk factors for the development of transposition of great arteries including first degree consanguineous marriages, gestational diabetes, family history of congenital cardiac anomalies, and increasing maternal age and parity. These factors increased the risk by at least 2 folds.
评估大动脉转位（TGA）发生的潜在危险因素及其影响。方法：对 1999 年至 2016 年在沙特阿拉伯利雅得阿卜杜勒阿齐兹国王医疗城诊断为 TGA 的所有患者进行回顾性病例对照研究。选择年龄和性别匹配的对照组。收集了包括近亲结婚、妊娠期糖尿病、先天性心脏病家族史、父母年龄和产妇产次在内的危险因素。回归模型用于分析危险因素对 TGA 发展的影响。结果：共纳入 206 例大动脉转位患者。大动脉转位病例分为单纯性和复杂性 TGA。选择了 446 名健康对照者。在研究病例中，95 例（46%）有近亲结婚史，36 例（17.5%）母亲被诊断为妊娠期糖尿病，35 例（17%）有明确的先天性心脏病家族史。将病例的危险因素与对照组进行比较，发现近亲结婚、妊娠期糖尿病、母亲年龄和产次显著增加了 TGA 的发生率。结论：我们的研究揭示了大动脉转位发生的显著危险因素，包括一级近亲结婚、妊娠期糖尿病、先天性心脏畸形家族史，以及母亲年龄和产次的增加。这些因素使风险至少增加了 2 倍。
