Behavioral Endocrinology Laboratory, Department of Psychology, Simon Fraser University, Canada.
Horm Behav. 2012 Apr;61(4):605-10. doi: 10.1016/j.yhbeh.2012.02.011. Epub 2012 Feb 17.
Bisphenol A (BPA) is an endocrine disrupting agent that can alter the normal gonadal steroid-sensitive sexual differentiation of the brain and behavior. While reproductive behavior and physiology are known to be altered by perinatal exposure to this compound, less is known about BPA's effects on sex differences in learning and measures of affect. In order to evaluate the effects of perinatal BPA treatment on learning and affect in adulthood, we exposed rats to one of five doses of BPA through gestation and lactation then examined adult behavior in the Morris Water Maze (MWM), the Elevated Plus Maze (EPM) and the Forced Swim Test (FST). No effect of BPA was observed in the MWM, but on both the EPM and FST, low doses (5 μg/kg) of BPA eliminated sex differences found between controls; furthermore, a non-monotonic dose-response observed in previous studies was confirmed for these tasks. Overall, our study adds to the growing data suggesting that BPA interferes with the normal development of affective behaviors in a non-linear, dose-dependent manner.
双酚 A（BPA）是一种内分泌干扰物，可改变大脑和行为的正常性腺类固醇敏感性性别分化。虽然已知围产期接触这种化合物会改变生殖行为和生理机能，但对 BPA 对学习和情感测量的性别差异的影响知之甚少。为了评估围产期 BPA 处理对成年期学习和情感的影响，我们通过妊娠和哺乳期将大鼠暴露于 BPA 的五种剂量之一，然后在 Morris 水迷宫（MWM）、高架十字迷宫（EPM）和强迫游泳试验（FST）中检查成年后的行为。BPA 在 MWM 中没有观察到影响，但在 EPM 和 FST 中，低剂量（5μg/kg）的 BPA 消除了对照组之间发现的性别差异；此外，在先前的研究中观察到的非单调剂量反应也在这些任务中得到了证实。总的来说，我们的研究增加了越来越多的数据，表明 BPA 以非线性、剂量依赖的方式干扰情感行为的正常发育。
