紫丹参酮型三萜与土木香二萜通过异狄尔斯-阿尔德反应形成的普氏紫堇烷：来自丹参的细胞毒加合物。
Przewalskone: a cytotoxic adduct of a danshenol type terpenoid and an icetexane diterpenoid via hetero-Diels-Alder reaction from Salvia przewalskii.
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China.
出版信息
Chem Commun (Camb). 2012 May 11;48(37):4438-40. doi: 10.1039/c2cc30405h. Epub 2012 Feb 27.
Przewalskone (1), an unprecedented adduct of two different terpenoid units via a hetero-Diels-Alder cycloaddition, was isolated from the roots of Salvia przewalskii. The structure and absolute configurations were elucidated by extensive analysis of NMR spectra and crystal X-ray diffractions. Compound 1 exhibited significant cytotoxicities against five human cancer lines in vitro (IC(50) 0.69-2.35 μM).
从藏丹参（Salvia przewalskii）的根部分离得到普氏马先蒿（1），这是一种前所未有的通过杂狄尔斯-阿尔德环加成反应连接两个不同萜烯单元的加合物。通过对 NMR 谱和晶体 X 射线衍射的广泛分析，阐明了其结构和绝对构型。化合物 1 在体外对五种人类癌细胞系表现出显著的细胞毒性（IC50 为 0.69-2.35 μM）。
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