萨尔普雷泽德斯 A 和 B：来自 Maxim 的两种具有抗血管生成活性的新型伊克替烷二萜

Salprzesides A and B: two novel icetexane diterpenes with antiangiogenic activity from Maxim.

机构信息

Department of Orthopaedics, The Second People's Hospital of Yibin, Sichuan, P.R. China.

出版信息

Nat Prod Res. 2022 May;36(10):2479-2485. doi: 10.1080/14786419.2021.1906666. Epub 2021 Apr 11.

DOI:10.1080/14786419.2021.1906666

Abstract

Two novel icetexane diterpenes were isolated from Maxim., namely Salprzesides A () and B (), together with two known abietane-type diterpenes respectively identified as sahandinone () and miltirone (). The structures of isolated compounds were determined by UV, IR, HR-ESI-MS, 1D and 2D NMR analysis. The antiangiogenic activities of compounds were studied against human umbilical vascular endothelial cells (HUVECs). The IC values of compounds 1-4 ranged from 4.22 ± 1.07 to 39.31 ± 2.17 μM against HUVECs.

摘要

从 Maxim. 中分离得到两种新型的冰烯二萜，分别命名为 Salprzesides A () 和 B ()，此外还分别分离得到两种已知的枞烷型二萜，鉴定为 sahandinone () 和 miltirone ()。通过 UV、IR、HR-ESI-MS、1D 和 2D NMR 分析确定了分离得到的化合物的结构。研究了化合物对人脐静脉内皮细胞（HUVEC）的抗血管生成活性。化合物 1-4 对 HUVEC 的 IC 值范围为 4.22 ± 1.07 至 39.31 ± 2.17 μM。