Castanea Diels f. pubescens 中的牛儿藤烯类化合物
Norditerpenoids from Salvia castanea Diels f. pubescens.
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China.
出版信息
Fitoterapia. 2012 Sep;83(6):1072-5. doi: 10.1016/j.fitote.2012.05.005. Epub 2012 May 17.
Three new norditerpenoids, castanol A-C (1-3), along with eighteen known diterpenoids, were isolated from Salvia castanea Diels f. pubescens. Their structures were elucidated by extensive spectroscopic analysis. All compounds were evaluated for their cytotoxic activities against five human cancer cell lines. The known compounds neo-tanshinlactone (12) and methyltanshinoate (17) exhibited significant cytotoxic activities against some cells.
从绵毛丹参中分离得到了三种新的降二萜类化合物，即castanol A-C（1-3），以及十八种已知的二萜类化合物。通过广泛的光谱分析阐明了它们的结构。所有化合物均对五种人癌细胞系进行了细胞毒性活性评估。已知化合物 neo-tanshinlactone（12）和 methyltanshinoate（17）对某些细胞表现出显著的细胞毒性活性。
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