Departement of Dermatology, Saint-Luc University Clinic, Louvain Catholic University, Bruxelles, Belgium.
G Ital Dermatol Venereol. 2012 Feb;147(1):65-9.
Corticosteroids are among the most commonly used drugs, both topically and systemically. Although unexpected and paradoxical, allergic hypersensitivity to corticosteroids is a common finding, delayed-type reactions being much more frequently encountered than the immediate-type ones. With regard to cross-reactions between corticosteroids, based on patch-test results and molecular modelling, we were recently able to simplify the previous classification into 3 different groups, i.e., Group 1: the non-methylated, most often non-halogenated molecules (Group A, D2 and budesonide), which produce most of the allergic reactions; Group 2: the halogenated molecules with a C16/C17 cis ketal/diol structure (acetonide Group B); and Group 3: the halogenated and C16-methylated molecules (Group C and D1) that only rarely produce allergy.
皮质类固醇是最常用的药物之一，包括局部和全身使用。尽管出乎意料和矛盾，但皮质类固醇过敏是一种常见的发现，迟发型反应比即刻型反应更常见。关于皮质类固醇之间的交叉反应，根据斑贴试验结果和分子建模，我们最近能够将以前的分类简化为 3 个不同的组，即第 1 组：非甲基化、最常非卤化分子（组 A、D2 和布地奈德），它们产生大多数过敏反应；第 2 组：具有 C16/C17 顺式缩酮/二醇结构的卤化分子（乙缩醛组 B）；第 3 组：卤化和 C16 甲基化分子（组 C 和 D1），它们很少引起过敏。
